{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T08:19:12Z","timestamp":1783066752214,"version":"3.54.6"},"reference-count":15,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Tukielin- ja plastiikkakirurgia (TuPla), HUS"},{"DOI":"10.13039\/100010135","name":"Finska L\u00e4kares\u00e4llskapet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010135","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008723","name":"Suomen L\u00e4\u00e4ketieteen S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","award":["7820"],"award-info":[{"award-number":["7820"]}],"id":[{"id":"10.13039\/100008723","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Scand J Surg"],"abstract":"<jats:sec>\n                    <jats:title>Background and aims:<\/jats:title>\n                    <jats:p>Perioperatively used, topically administered tranexamic acid (TXA) has attracted increasing interest in plastic surgery, and several studies have compared the effectiveness and safety of topical and intravenous (IV) administration. Topical TXA has been reported to have an equal or superior effect in reducing postoperative bleeding and transfusion requirements, with no increase in reported adverse events. Although prophylactic topical TXA is believed to result in cost savings, cost-effectiveness analyses concerning the use of TXA in breast surgery have not yet been reported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This single-center, retrospective cohort study calculated the costs for all patients who underwent reduction mammaplasty between 2019 and 2021 at Jorvi Hospital, Finland. We compared postoperative complications and total healthcare costs associated with surgery between two groups: patients who received topical TXA perioperatively (TXA group) and patients who did not receive TXA (non-TXA group). Total costs were analyzed, including both the intraoperative and postoperative periods. All costs were calculated in euros, based on the 2020 Helsinki University Hospital (HUS) rates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>In 328 breast reduction surgeries, the leading postoperative costs were caused by reoperations, and additional ward stays due to complications. The cost of TXA irrigation itself was negligible compared with the other expenses. The median postoperative costs were \u20ac414 in the non-TXA group and \u20ac335 in the TXA group, and the mean postoperative costs were \u20ac874 in the non-TXA group and \u20ac453 in the TXA group (p\u2009=\u20090.002). In the non-TXA group, 11 patients (6.1%) underwent reoperation for hematoma and four (2.2%) for other wound-healing complications. In contrast, in the TXA group only one (0.7%) patient required reoperation for hematoma and one (0.7%) for wound-healing complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This study demonstrates that the application of this low-cost drug may reduce the overall costs associated with reduction mammaplasty.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/14574969261461398","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T09:42:02Z","timestamp":1782812522000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Cost efficiency of topical tranexamic acid in reduction mammaplasty surgeries"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0016-8551","authenticated-orcid":false,"given":"Krisztina","family":"Sipos","sequence":"first","affiliation":[{"name":"Department of Musculoskeletal and Plastic Surgery University of Helsinki and Helsinki University Hospital Stenb\u00e4ckinkatu 1100290 Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9427-7689","authenticated-orcid":false,"given":"Mervi","family":"Rautalin","sequence":"additional","affiliation":[{"name":"Department of Musculoskeletal and Plastic Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4430-6979","authenticated-orcid":false,"given":"Kaisu","family":"Ojala","sequence":"additional","affiliation":[{"name":"Department of Musculoskeletal and Plastic Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7027-4080","authenticated-orcid":false,"given":"Susanna","family":"Kauhanen","sequence":"additional","affiliation":[{"name":"Department of Musculoskeletal and Plastic Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland"},{"name":"Department of Plastic and Maxillofacial Surgery, Akademiska Sjukhuset, Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,6,30]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2011.07.028"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clbc.2025.01.011"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2023.04.039"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs5.50248"},{"key":"e_1_3_3_6_2","unstructured":"Sepp\u00e4l\u00e4 TT Pekurinen M: Sosiaali- ja terveydenhuollon keskeiset rahavirrat. Juvenes Print\u2014Suomen Yliopistopaino Oy Tampere 2014."},{"key":"e_1_3_3_7_2","unstructured":"https:\/\/www.finlex.fi\/fi\/lainsaadanto\/1992\/734#sec_6a (accessed 21 December 2025)."},{"key":"e_1_3_3_8_2","unstructured":"https:\/\/www.eu-healthcare.fi\/legislation\/ (accessed 21 December 2025)."},{"key":"e_1_3_3_9_2","unstructured":"https:\/\/www.hus.fi\/en\/patient\/patient-guide\/after-treatment\/client-fees (accessed 21 December 2025)."},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rcsop.2021.100039"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-022-05775-y"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2014.01.031"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.L.00907"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2013.06.037"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2016.05.008"},{"issue":"12","key":"e_1_3_3_16_2","article-title":"Reduction mammaplasty in adolescents: A comparison of wise and vertical incision patterns","volume":"7","author":"Kulkarni K","year":"2019","unstructured":"Kulkarni K, Egro FM, Kenny EM, et al: Reduction mammaplasty in adolescents: A comparison of wise and vertical incision patterns. 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