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A total of 197 Italian general practitioners were randomly allocated to receive either the alerting computerized decision support system integrated into standard software (intervention arm) or the standard software alone (control arm). Data on 21230 patients with diabetes, 3956 with acute myocardial infarction, and 2158 with stroke were analysed. The proportion of patients prescribed with cardiovascular drugs and days of drug\u2013drug interaction exposure were evaluated. Computerized decision support system significantly increased the proportion of patients with diabetes prescribed with antiplatelet drugs (intervention: +2.7% vs. control: +0.15%; p &lt; 0.001) or lipidlowering drugs (+4.2% vs. +2.8%; p = 0.001). A statistically significant decrease in days of potential interactions has been observed only among patients with stroke (\u22121.2 vs. \u22120.5 days\/person-year; p = 0.001). In conclusion, computerized decision support system significantly increased the use of recommended cardiovascular drugs in diabetic patients, but it did not influence the exposure to potential interactions<\/jats:p>","DOI":"10.1177\/1460458214546773","type":"journal-article","created":{"date-parts":[[2014,9,11]],"date-time":"2014-09-11T01:01:05Z","timestamp":1410397265000},"page":"232-247","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":17,"title":["Effects of a computerized decision support system in improving pharmacological management in high-risk cardiovascular patients: A cluster-randomized open-label controlled trial"],"prefix":"10.1177","volume":"22","author":[{"given":"Giampiero","family":"Mazzaglia","sequence":"first","affiliation":[{"name":"Italian College of General Practitioners, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Piccinni","sequence":"additional","affiliation":[{"name":"University of Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Filippi","sequence":"additional","affiliation":[{"name":"Italian College of General Practitioners, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanna","family":"Sini","sequence":"additional","affiliation":[{"name":"Italian College of General Practitioners, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Lapi","sequence":"additional","affiliation":[{"name":"Italian College of General Practitioners, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emiliano","family":"Sessa","sequence":"additional","affiliation":[{"name":"Italian College of General Practitioners, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iacopo","family":"Cricelli","sequence":"additional","affiliation":[{"name":"Italian College of General Practitioners, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Cutroneo","sequence":"additional","affiliation":[{"name":"University of Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianluca","family":"Trifir\u00f2","sequence":"additional","affiliation":[{"name":"University of Messina, Italy; 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