{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T23:48:15Z","timestamp":1777852095341,"version":"3.51.4"},"reference-count":33,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2017,12,17]],"date-time":"2017-12-17T00:00:00Z","timestamp":1513468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Health Informatics J"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:p>We validate our previously developed (DOI: 10.1101\/089227) clinical prediction rule for diagnosing transient ischemic attack on the basis of presenting clinical symptoms and compare its performance with the ABCD2 score in first-contact patient settings. Two independent and prospectively collected patient validation cohorts were used: (a) referral cohort\u2013prospectively referred emergency department and general practitioner patients ( N = 877); and (b) SpecTRA cohort\u2013participants recruited as part of the SpecTRA biomarker project ( N = 545). Outcome measure consisted of imaging-confirmed clinical diagnosis of mild stroke\/transient ischemic attack. Results showed that our clinical prediction rule demonstrated significantly higher accuracy than the ABCD2 score for both the referral cohort (70.5% vs 59.0%; p &lt; 0.001) and SpecTRA cohort (72.8% vs 68.3%; p = 0.028). We discuss the potential of our clinical prediction rule to replace the use of the ABCD2 score in the triage of transient ischemic attack clinic referrals.<\/jats:p>","DOI":"10.1177\/1460458217747111","type":"journal-article","created":{"date-parts":[[2017,12,18]],"date-time":"2017-12-18T06:29:18Z","timestamp":1513578558000},"page":"1148-1157","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Validation of a multivariate clinical prediction model for the diagnosis of mild stroke\/transient ischemic attack in physician first-contact patient settings"],"prefix":"10.1177","volume":"25","author":[{"given":"Maximilian B","family":"Bibok","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew M","family":"Penn","sequence":"additional","affiliation":[{"name":"Vancouver Island Health Authority, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary L","family":"Lesperance","sequence":"additional","affiliation":[{"name":"University of Victoria, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristine","family":"Votova","sequence":"additional","affiliation":[{"name":"Vancouver Island Health Authority, Canada; University of Victoria, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Balshaw","sequence":"additional","affiliation":[{"name":"British Columbia Centre for Disease Control, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,12,17]]},"reference":[{"key":"bibr1-1460458217747111","doi-asserted-by":"publisher","DOI":"10.1038\/ncpcardio0679"},{"key":"bibr2-1460458217747111","doi-asserted-by":"publisher","DOI":"10.1111\/ijs.12439"},{"key":"bibr3-1460458217747111","unstructured":"National Institute for Health Care Excellence (NICE). 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