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The goal of this study is to systematically review studies that focused on the usability aspects such as effectiveness, efficiency, and satisfaction of these systems. We systematically searched relevant articles in Scopus, Embase, and PubMed from 1 January 2000 to 1 January 2016, and found 22 articles. Based on Van Welie\u2019s usability model, we categorized usability aspects in terms of usage indicators and means. Our results showed that evidence was mainly found for effectiveness and efficiency. They showed positive results in the usage indicators errors and safety and performance speed. The means warnings and adaptability also had mostly positive results. To date, the effects satisfaction of clinical decision support system remains understudied. Aspects such as memorability, learnability, and consistency require more attention.<\/jats:p>","DOI":"10.1177\/1460458219841167","type":"journal-article","created":{"date-parts":[[2019,4,24]],"date-time":"2019-04-24T03:35:51Z","timestamp":1556076951000},"page":"613-627","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["The usability aspects of medication-related decision support systems in the inpatient setting: A systematic review"],"prefix":"10.1177","volume":"26","author":[{"given":"Bram","family":"Knols","sequence":"first","affiliation":[{"name":"Utrecht University, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathijs","family":"Louws","sequence":"additional","affiliation":[{"name":"Erasmus University Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4929-0064","authenticated-orcid":false,"given":"Alec","family":"Hardenbol","sequence":"additional","affiliation":[{"name":"Utrecht University, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jamshid","family":"Dehmeshki","sequence":"additional","affiliation":[{"name":"Kingstone University, England"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7473-0132","authenticated-orcid":false,"given":"Marjan","family":"Askari","sequence":"additional","affiliation":[{"name":"Erasmus University Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,4,24]]},"reference":[{"key":"bibr1-1460458219841167","volume-title":"To err is human: building a safer health system","volume":"6","author":"Kohn LT","year":"2000"},{"key":"bibr2-1460458219841167","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1997.03540280045032"},{"key":"bibr3-1460458219841167","doi-asserted-by":"publisher","DOI":"10.1002\/pds.3415"},{"key":"bibr4-1460458219841167","unstructured":"Askari M. 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