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While preclinical experiments suggest that adolescent-onset exposure to attention deficit hyperactivity disorder medication is an important factor in the development of substance use disorder phenotypes in adulthood, the long-term impact of attention deficit hyperactivity disorder medication initiated during adolescence has been largely unexplored in humans. Our analysis of 11,624 adolescent enrollees with attention deficit hyperactivity disorder in the Truven database indicates that temporal medication features, rather than stationary features, are the most important factors on the health consequences related to substance use disorder and attention deficit hyperactivity disorder medication initiation during adolescence.<\/jats:p>","DOI":"10.1177\/1460458219844075","type":"journal-article","created":{"date-parts":[[2019,5,20]],"date-time":"2019-05-20T02:59:08Z","timestamp":1558321148000},"page":"787-802","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Predicting substance use disorder using long-term attention deficit hyperactivity disorder medication records in Truven"],"prefix":"10.1177","volume":"26","author":[{"given":"Sajjad","family":"Fouladvand","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily R","family":"Hankosky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heather","family":"Bush","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2240-5060","authenticated-orcid":false,"given":"Jin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda P","family":"Dwoskin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia R","family":"Freeman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darren W","family":"Henderson","sequence":"additional","affiliation":[{"name":"University of Kentucky, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen","family":"Kantak","sequence":"additional","affiliation":[{"name":"Boston University, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffery","family":"Talbert","sequence":"additional","affiliation":[{"name":"University of Kentucky, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiqiang","family":"Tao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guo-Qiang","family":"Zhang","sequence":"additional","affiliation":[{"name":"University of Kentucky, USA; The University of Texas Health Science Center at Houston, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,5,19]]},"reference":[{"key":"bibr1-1460458219844075","unstructured":"Behavioral health trends in the United States: results from the 2014 national survey on drug use and health\n                      . 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