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Predicting survival of patients with HCC remains an important challenge, especially because technologies needed for this scope are not available in all hospitals. In this context, machine learning applied to medical records can be a fast, low-cost tool to predict survival and detect the most predictive features from health records. In this study, we analyzed medical data of 165 patients with HCC: we employed computational intelligence to predict their survival, and to detect the most relevant clinical factors able to discriminate survived from deceased cases. Afterwards, we compared our data mining results with those obtained through statistical tests and scientific literature findings. Our analysis revealed that blood levels of alkaline-phosphatase (ALP), alpha-fetoprotein (AFP), and hemoglobin are the most effective prognostic factors in this dataset. We found literature supporting association of these three factors with hepatoma, even though only AFP has been used in a prognostic index. Our results suggest that ALP and hemoglobin can be candidates for future HCC prognostic indexes, and that physicians could focus on ALP, AFP, and hemoglobin when studying HCC records.<\/jats:p>","DOI":"10.1177\/1460458220984205","type":"journal-article","created":{"date-parts":[[2021,1,28]],"date-time":"2021-01-28T03:14:32Z","timestamp":1611803672000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":22,"title":["Computational intelligence identifies alkaline phosphatase (ALP), alpha-fetoprotein (AFP), and hemoglobin levels as most predictive survival factors for hepatocellular carcinoma"],"prefix":"10.1177","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9655-7142","authenticated-orcid":false,"given":"Davide","family":"Chicco","sequence":"first","affiliation":[{"name":"Krembil Research Institute, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Oneto","sequence":"additional","affiliation":[{"name":"Universit\u00e0 di Genova, Italy; ZenaByte Srl"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,1,27]]},"reference":[{"issue":"3","key":"bibr1-1460458220984205","first-page":"141","volume":"22","author":"Rawla P","year":"2018","journal-title":"Contemp Oncol (Pozn)"},{"key":"bibr2-1460458220984205","unstructured":"American Cancer Society. 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