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With recent advances in digital infrastructure and the advent of electronically available health records, linkage of routinely collected data has emerged as a promising evaluation method for these studies. This paper discusses the opportunities and challenges when applying an electronic record linkage methodology with respect to systemic anti-cancer therapy by showcasing exemplar studies conducted over a three-year period in Scotland, and highlights some of the potential pitfalls spanning the entire breadth and depth of the research process. Our experiences as an interdisciplinary team indicate that there is scope to conduct large cohort studies to generate results from routine clinical practice within a reasonable time frame; however, close collaboration between researchers, data controllers and clinicians is required in order to obtain valid and meaningful results.<\/jats:p>","DOI":"10.1177\/14604582221077055","type":"journal-article","created":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T07:23:08Z","timestamp":1645600988000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Opportunities and challenges when using record linkage of routinely collected electronic health care data to evaluate outcomes of systemic anti-cancer treatment in clinical practice"],"prefix":"10.1177","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0418-4789","authenticated-orcid":false,"given":"Tanja","family":"Mueller","sequence":"first","affiliation":[{"name":"Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK"}]},{"given":"Jennifer","family":"Laskey","sequence":"additional","affiliation":[{"name":"NHS Greater Glasgow & Clyde, Glasgow, UK"}]},{"given":"Kelly","family":"Baillie","sequence":"additional","affiliation":[{"name":"NHS Greater Glasgow & Clyde, Glasgow, UK"}]},{"given":"Julie","family":"Clarke","sequence":"additional","affiliation":[{"name":"NHS Greater Glasgow & Clyde, Glasgow, UK"}]},{"given":"Christine","family":"Crearie","sequence":"additional","affiliation":[{"name":"NHS Greater Glasgow & Clyde, Glasgow, UK"}]},{"given":"Kimberley","family":"Kavanagh","sequence":"additional","affiliation":[{"name":"Department of Mathematics & Statistics, University of Strathclyde, Glasgow, UK"}]},{"given":"Janet","family":"Graham","sequence":"additional","affiliation":[{"name":"Beatson West of Scotland Cancer Centre, NHS Greater Glasgow & Clyde, Glasgow, UK"},{"name":"Institute of Cancer Sciences, University of Glasgow, Glasgow, UK"}]},{"given":"Kathryn","family":"Graham","sequence":"additional","affiliation":[{"name":"Beatson West of Scotland Cancer Centre, NHS Greater Glasgow & Clyde, Glasgow, UK"}]},{"given":"Ashita","family":"Waterson","sequence":"additional","affiliation":[{"name":"Beatson West of Scotland Cancer Centre, NHS Greater Glasgow & Clyde, Glasgow, UK"}]},{"given":"Robert","family":"Jones","sequence":"additional","affiliation":[{"name":"Institute of Cancer Sciences, University of Glasgow, Glasgow, UK"}]},{"given":"Amanj","family":"Kurdi","sequence":"additional","affiliation":[{"name":"Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK"},{"name":"Department of Pharmacology, College of Pharmacy, Hawler Medical University, Erbil, Iraq"},{"name":"Division of Public Health Pharmacy and Management, School of Pharmacy, Sefako Makgatho Health Sciences University, Ga-Rankuwa, South Africa"}]},{"given":"David","family":"Morrison","sequence":"additional","affiliation":[{"name":"Public Health Scotland, Edinburgh, UK"}]},{"given":"Marion","family":"Bennie","sequence":"additional","affiliation":[{"name":"Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK"},{"name":"Public Health Scotland, Edinburgh, UK"}]}],"member":"179","published-online":{"date-parts":[[2022,2,23]]},"reference":[{"key":"bibr1-14604582221077055","doi-asserted-by":"publisher","DOI":"10.1787\/4dd50c09-en"},{"key":"bibr2-14604582221077055","volume-title":"Ageing","author":"United Nations"},{"key":"bibr3-14604582221077055","volume-title":"Mid-2019 Population Estimates Scotland. 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