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This study seeks to investigate whether Monitoring &amp; Evaluation (M&amp;E) officers in Ghana will be willing to join in an electronic learning platform which is web-based as a means of building M&amp;E capacity. Methods: 123 out of 130 participants were involved in the study. Continuous and categorical variables were analysed using means and proportions. Structural equation Modelling technique was used to determine the factors associated with acceptability\/intention to use. Results: The results showed that Attitude toward usage had a positive significant influence on acceptability\/intention to use (AITU). In addition, experience with online learning and Internet discussion also had a positive influence on perceived usefulness and perceived ease of use respectively. The overall model shows 71% of variation of M&amp;E officers\u2019 attitude toward usage on acceptability\/intention to use online M&amp;E platform as observed by the covariates in the model. Conclusions: Attitude toward usage was observed to be the strongest determinant of the AITU online HIV\/AIDS M&amp;E platform for monitoring and evaluation activities.<\/jats:p>","DOI":"10.1177\/14604582231152782","type":"journal-article","created":{"date-parts":[[2023,1,16]],"date-time":"2023-01-16T12:11:46Z","timestamp":1673871106000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploring factors influencing acceptability of online capacity building platform for HIV and AIDS monitoring and evaluation in Ghana"],"prefix":"10.1177","volume":"29","author":[{"given":"Samuel KK","family":"Dery","sequence":"first","affiliation":[{"name":"Department of Biostatistics, School of Public Health, College of Health Sciences, University of Ghana, Legon, Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frances Baaba","family":"da-Costa Vroom","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, School of Public Health, College of Health Sciences, University of Ghana, Legon, Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charity K","family":"Asem","sequence":"additional","affiliation":[{"name":"School of Public Health, College of Health Sciences, University of Ghana, Legon, Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6916-6733","authenticated-orcid":false,"given":"Godwin","family":"Adzakpah","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, School of Public Health, College of Health Sciences, University of Ghana, Legon, Ghana"},{"name":"Department of Health Information Management, College of Health and Allied Sciences, School of Allied Health Sciences, University of Cape Coast, Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,1,16]]},"reference":[{"key":"bibr1-14604582231152782","doi-asserted-by":"publisher","DOI":"10.2991\/jegh.k.191208.001"},{"key":"bibr2-14604582231152782","doi-asserted-by":"publisher","DOI":"10.3855\/jidc.6588"},{"key":"bibr3-14604582231152782","unstructured":"WHO. 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