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Polysomnography has been considered to identify MDD. However, limited access to sleep clinics makes this challenging. In this study, we propose a model to detect MDD in people with OSA using an electrocardiogram (ECG) during sleep. Methods: The single-lead ECG data of 32 people with OSA (OSAD-) and 23 with OSA and MDD (OSAD+) were investigated. The first 60\u00a0min of their recordings after sleep were segmented into 30-s segments and 13 parameters were extracted: PR, QT, ST, QRS, PP, and RR; mean heart rate; two time-domain HRV parameters: SDNN, RMSSD; and four frequency heart rate variability parameters: LF_power, HF_power, total power, and the ratio of LF_power\/HF_power. The mean and standard deviation of these parameters were the input to a support vector machine which was trained to separate OSAD- and OSAD+. Results: The proposed model distinguished between OSAD+ and OSAD- groups with an accuracy of 78.18%, a sensitivity of 73.91%, a specificity of 81.25%, and a precision of 73.91%. Conclusion: This study shows the potential of using only ECG for detecting depression in OSA patients.<\/jats:p>","DOI":"10.1177\/14604582241300012","type":"journal-article","created":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T04:48:10Z","timestamp":1732164490000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Screening major depressive disorder in patients with obstructive sleep apnea using single-lead ECG recording during sleep"],"prefix":"10.1177","volume":"30","author":[{"given":"Vikash","family":"Shaw","sequence":"first","affiliation":[{"name":"Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India"},{"name":"CSIR-Central Scientific Instruments Organisation (CSIR-CSIO), Chandigarh, India"},{"name":"School of Engineering, STEM College, RMIT University, Melbourne, VIC, Australia"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8071-5342","authenticated-orcid":false,"given":"Quoc Cuong","family":"Ngo","sequence":"additional","affiliation":[{"name":"School of Engineering, STEM College, RMIT University, Melbourne, VIC, Australia"}]},{"given":"Nemuel Daniel","family":"Pah","sequence":"additional","affiliation":[{"name":"School of Engineering, STEM College, RMIT University, Melbourne, VIC, Australia"}]},{"given":"Guilherme","family":"Oliveira","sequence":"additional","affiliation":[{"name":"School of Engineering, STEM College, RMIT University, Melbourne, VIC, Australia"}]},{"given":"Ahsan Habib","family":"Khandoker","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering and Biotechnology, Khalifa University, Abu Dhabi, UAE"}]},{"given":"Prasant Kumar","family":"Mahapatra","sequence":"additional","affiliation":[{"name":"Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India"},{"name":"CSIR-Central Scientific 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