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LinkAll leverages Edge-Computing and Internet of Things principles to handle data collection, processing, and presentation from various sources.\n                    <jats:bold>Methods:<\/jats:bold>\n                    Two sibling systems were implemented to demonstrate its capability, one for monitoring urban greenery and the other for elderly home care. These systems were evaluated based on their ability to integrate with existing information systems, collect biophysical parameters, and ensure data cross-referencing.\n                    <jats:bold>Results:<\/jats:bold>\n                    Both systems demonstrate effective pluggability and cross-referenceability performances, meeting the stakeholders\u2019 requirements. LinkAll\u2019s ability to integrate diverse sensors and devices into existing infrastructures while providing real-time, machine-actionable insights, is also underscored.\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    Pluggability, cross-referenceability, and compliance with FAIR principles make the architectural model introduced a robust solution for integrating human, animal, and environmental health monitoring systems, enhancing decision-making and contributing to One (Digital) Health\u2019s strategic goals.\n                  <\/jats:p>","DOI":"10.1177\/14604582251383803","type":"journal-article","created":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T17:51:46Z","timestamp":1770486706000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["A cloud\u2013edge reference architecture for intertwining health digital domains"],"prefix":"10.1177","volume":"32","author":[{"given":"Adriano","family":"Tramontano","sequence":"first","affiliation":[{"name":"Institute of Biostructures and Bioimaging (IBB\u2013CNR)"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0130-7915","authenticated-orcid":false,"given":"Oscar","family":"Tamburis","sequence":"additional","affiliation":[{"name":"Institute of Biostructures and Bioimaging (IBB\u2013CNR)"}]},{"given":"Giulio","family":"Perillo","sequence":"additional","affiliation":[{"name":"GESAN srl"}]},{"given":"Guido","family":"Iaccarino","sequence":"additional","affiliation":[{"name":"Federico II University of Naples"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9125-8300","authenticated-orcid":false,"given":"Arriel","family":"Benis","sequence":"additional","affiliation":[{"name":"Holon Institute of Technology"}]},{"given":"Mario","family":"Magliulo","sequence":"additional","affiliation":[{"name":"Institute of Biostructures and Bioimaging (IBB\u2013CNR)"}]}],"member":"179","published-online":{"date-parts":[[2026,2,7]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.1145\/3041960"},{"key":"e_1_3_7_3_2","doi-asserted-by":"crossref","unstructured":"Junior RL. 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