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The system aims to strengthen patient engagement and proactive care by enabling healthcare practitioners (HCP) to assign dynamic, data-driven and personalized mitigation plans. Central to this system is a user interface that allows HCP to review and assign tailored mitigation plans to patients. These plans are formulated based on primary clinical data and enriched with secondary behavioral data, such as wearable-derived metrics and self-reported inputs. These inputs are continuously collected, transformed into Holistic Health Records (HHRs), and stored in a scalable platform for integration with ML-based trend analysis and visualization. The article outlines the system\u2019s technical architecture, patient data evaluation logic, and user experience across both the HCP interface and patient app. Evaluation by end users via questionnaires demonstrated improved adherence to plans and higher-quality behavioral data. This monitoring platform offers a promising tool for facilitating early risk intervention in pancreatic cancer care. By integrating multi-source patient data into actionable strategies and fostering bidirectional engagement, it bridges the gap between clinical insight and patient participation, contributing to holistic health management.<\/jats:p>","DOI":"10.1177\/14604582251387969","type":"journal-article","created":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T06:00:25Z","timestamp":1760594425000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Advanced monitoring, alerting and feedback in early risk mitigation for pancreatic cancer"],"prefix":"10.1177","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0128-2022","authenticated-orcid":false,"given":"George","family":"Manias","sequence":"first","affiliation":[{"name":"University of Piraeus"},{"name":"Tilburg University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelina","family":"Angelova","sequence":"additional","affiliation":[{"name":"Innovation Sprint"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Kirova","sequence":"additional","affiliation":[{"name":"Strypes ICT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9623-6354","authenticated-orcid":false,"given":"Aristodemos","family":"Pnevmatikakis","sequence":"additional","affiliation":[{"name":"Innovation Sprint"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pencho","family":"Stefanov","sequence":"additional","affiliation":[{"name":"Strypes ICT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Melillo","sequence":"additional","affiliation":[{"name":"Engineering Ingegneria Informatica SpA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar Garcia","family":"Perales","sequence":"additional","affiliation":[{"name":"Information Catalyst, SL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantina","family":"Kostopoulou","sequence":"additional","affiliation":[{"name":"Innovation Sprint"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofoklis","family":"Kyriazakos","sequence":"additional","affiliation":[{"name":"Innovation Sprint"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimosthenis","family":"Kyriazis","sequence":"additional","affiliation":[{"name":"University of Piraeus"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,10,15]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"crossref","unstructured":"Paschou M Sakkopoulos E. 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