{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T14:10:29Z","timestamp":1762092629601,"version":"build-2065373602"},"reference-count":84,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Health Informatics J"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    Human Digital Twins (HDTs) have recently emerged, especially in the context of healthcare. With the growing emphasis on preventive healthcare beyond diagnosis, pervasive sensing has become essential which enables continuous monitoring through real-world data captured from wearables and\/or mobile devices.\n                    <jats:bold>Objective:<\/jats:bold>\n                    This scoping review investigates how pervasive sensing technologies have been utilized in the implementation of HDTs for healthcare, with a focus on understanding the twinning methods, identifying their advantages and limitations, and uncovering key challenges encountered in real-world applications.\n                    <jats:bold>Methods:<\/jats:bold>\n                    We proposed an analytical framework to examine how pervasive sensing technologies are utilized in the implementation of HDTs for personal health management. Using this framework, we conducted a comprehensive literature search across PubMed, Scopus, IEEE Xplore, Web of Science, and Google Scholar.\n                    <jats:bold>Results:<\/jats:bold>\n                    A total of 39 eligible papers were reviewed. We present an analysis of these studies and provide a discussion on the potential and limitations of HDTs in the context of pervasive healthcare.\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    The key takeaway is that the integration of HDTs and pervasive sensing provides a foundation for realizing pervasive healthcare by enabling not one-time digital replication, but continuous and comprehensive monitoring of individuals, including their surrounding environments and behavioral changes.\n                  <\/jats:p>","DOI":"10.1177\/14604582251392455","type":"journal-article","created":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:30:19Z","timestamp":1761863419000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Human Digital Twins for pervasive healthcare: A scoping review"],"prefix":"10.1177","volume":"31","author":[{"given":"Joonyoung","family":"Park","sequence":"first","affiliation":[{"name":"KAIST"}]},{"given":"Eunji","family":"Park","sequence":"additional","affiliation":[{"name":"Chung-Ang University"}]},{"given":"Duri","family":"Lee","sequence":"additional","affiliation":[{"name":"KAIST"}]},{"given":"Soowon","family":"Kang","sequence":"additional","affiliation":[{"name":"KAIST"}]},{"given":"Takyeon","family":"Lee","sequence":"additional","affiliation":[{"name":"KAIST"}]},{"given":"Hwajung","family":"Hong","sequence":"additional","affiliation":[{"name":"KAIST"}]},{"given":"Sung-Ju","family":"Lee","sequence":"additional","affiliation":[{"name":"KAIST"}]},{"given":"Heepyung","family":"Kim","sequence":"additional","affiliation":[{"name":"KAIST"}]},{"given":"Yu Rang","family":"Park","sequence":"additional","affiliation":[{"name":"Yonsei University"}]},{"given":"Uichin","family":"Lee","sequence":"additional","affiliation":[{"name":"KAIST"}]}],"member":"179","published-online":{"date-parts":[[2025,10,30]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11036-007-0017-1"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.comnet.2010.05.003"},{"key":"e_1_3_4_4_2","first-page":"487","article-title":"The relative contribution of multiple determinants to health","volume":"10","author":"McGovern L","year":"2014","unstructured":"McGovern L, G. M., and Hughes-Cromwick P. The relative contribution of multiple determinants to health, Health Affairs Health Policy Brief 10, 2014. 487.","journal-title":"Health Affairs Health Policy Brief"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.3109\/09540261.2014.928270"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1109\/ACCESS.2019.2953499"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-84628-943-9_11"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1109\/WMCSA.1994.16"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1177\/0272989X10373805"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-39512-4_97"},{"key":"e_1_3_4_11_2","first-page":"273","volume-title":"International conference on ubiquitous computing","author":"Langheinrich M","year":"2001","unstructured":"Langheinrich M. Privacy by Design\u2014Principles of privacy-aware ubiquitous systems. International conference on ubiquitous computing. Springer Berlin Heidelberg, 2001, pp. 273\u2013291."},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1109\/MPRV.2022.3210747"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.procir.2021.11.077"},{"key":"e_1_3_4_14_2","unstructured":"Marshall T. Vph: the ultimate stage before your own medical digital twin. (2019) [Online]. Available. https:\/\/www.linkedin.com\/pulse\/vph-ultimate-stage-before-your-own-medical-digital-twin-marchal\/"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s42454-022-00041-x"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmpbup.2021.100014"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnbot.2021.789743"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1109\/JIOT.2022.3156028"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.3390\/s22249747"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1109\/JIOT.2023.3267171"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1109\/LRA.2022.3183253"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/cnm.3180"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00264-021-05175-2"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1109\/TCE.2024.3375920"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41746-024-01073-0"},{"key":"e_1_3_4_26_2","first-page":"7922","article-title":"Towards the human digital twin: definition and Design--A survey","volume":"1","author":"Lauer-Schmaltz MW","year":"2024","unstructured":"Lauer-Schmaltz MW, Cash P, Hansen JP, et al. Towards the human digital twin: definition and Design--A survey. arXiv preprint 2024; 1: 7922.","journal-title":"arXiv preprint"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1109\/ACCESS.2023.3349379"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1177\/20552076221149651"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1017\/pds.2022.132"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-99-3989-3_4"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1109\/ACCESS.2024.3416517"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12874-018-0611-x"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.7326\/M18-0850"},{"issue":"4","key":"e_1_3_4_34_2","first-page":"336","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the prisma statement","volume":"8","author":"Moher D","year":"2009","unstructured":"Moher D, Liberati A, Tetzlaff J, et al. and PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: the prisma statement. Int J Surg 2009; 8(4): 336\u2013341.","journal-title":"Int J Surg"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1109\/MIM.2021.9513635"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-99-3581-9_2"},{"key":"e_1_3_4_37_2","first-page":"1","volume-title":"2022 IEEE International Conference on Consumer Electronics (ICCE)","author":"Kobayashi T","year":"2022","unstructured":"Kobayashi T, Fukae K, Imai T, et al. Digital twin agent for superaged society. 2022 IEEE International Conference on Consumer Electronics (ICCE). IEEE, 2022, pp. 1\u20136."},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.3390\/machines10070530"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-022-02144-y"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.3390\/bioengineering10040455"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1109\/CISAI54367.2021.00182"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.3233\/THC-220087"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.1080\/10717544.2022.2050846"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.1055\/a-1253-8558"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12062094"},{"key":"e_1_3_4_46_2","doi-asserted-by":"publisher","DOI":"10.1109\/JIOT.2021.3051158"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.1109\/MeMeA.2019.8802162"},{"key":"e_1_3_4_48_2","first-page":"3988166","article-title":"3d visualization analysis of motion trajectory of knee joint in sports training based on digital twin","volume":"2022","author":"Chen J","year":"2022","unstructured":"Chen J. 3d visualization analysis of motion trajectory of knee joint in sports training based on digital twin. Comput Intell Neurosci 2022; 2022: 3988166.","journal-title":"Comput Intell Neurosci"},{"key":"e_1_3_4_49_2","volume-title":"Patient-generated health data","author":"Shapiro M","year":"2012","unstructured":"Shapiro M, Johnston D, Wald J, et al. Patient-generated health data. RTI International, 2012. [Online]. Available. https:\/\/www.rti.org\/sites\/default\/files\/resources\/patientgeneratedhealthdata.pdf"},{"key":"e_1_3_4_50_2","doi-asserted-by":"publisher","DOI":"10.1145\/3469260.3469670"},{"key":"e_1_3_4_51_2","doi-asserted-by":"publisher","DOI":"10.1109\/ACCESS.2019.2909828"},{"key":"e_1_3_4_52_2","doi-asserted-by":"publisher","DOI":"10.1109\/iSES54909.2022.00149"},{"key":"e_1_3_4_53_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10916-020-01623-5"},{"key":"e_1_3_4_54_2","doi-asserted-by":"publisher","DOI":"10.1109\/LRA.2021.3082012"},{"key":"e_1_3_4_55_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-94339-6"},{"key":"e_1_3_4_56_2","doi-asserted-by":"publisher","DOI":"10.1109\/ACCESS.2020.2971576"},{"key":"e_1_3_4_57_2","doi-asserted-by":"publisher","DOI":"10.1109\/GCWkshps52748.2021.9681996"},{"key":"e_1_3_4_58_2","doi-asserted-by":"publisher","DOI":"10.1109\/ACCESS.2023.3348783"},{"key":"e_1_3_4_59_2","doi-asserted-by":"publisher","DOI":"10.3390\/bioengineering10060627"},{"key":"e_1_3_4_60_2","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2021.652907"},{"key":"e_1_3_4_61_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-58799-4_37"},{"key":"e_1_3_4_62_2","doi-asserted-by":"publisher","DOI":"10.1109\/ACCESS.2022.3193941"},{"key":"e_1_3_4_63_2","doi-asserted-by":"publisher","DOI":"10.1561\/9781680838770.ch7"},{"key":"e_1_3_4_64_2","doi-asserted-by":"publisher","DOI":"10.3390\/app10217758"},{"key":"e_1_3_4_65_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10237-020-01393-6"},{"key":"e_1_3_4_66_2","doi-asserted-by":"publisher","DOI":"10.1080\/21693277.2019.1660283"},{"key":"e_1_3_4_67_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12160-016-9830-8"},{"key":"e_1_3_4_68_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12966-019-0792-7"},{"key":"e_1_3_4_69_2","doi-asserted-by":"publisher","DOI":"10.1145\/3613904.3642832"},{"key":"e_1_3_4_70_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1145\/3546749","article-title":"EatingTrak: detecting fine-grained eating moments in the wild using a wrist-mounted IMU","volume":"6","author":"Zhang R","year":"2022","unstructured":"Zhang R, Zhang J, Gade N, et al. EatingTrak: detecting fine-grained eating moments in the wild using a wrist-mounted IMU. Proc ACM Hum Comput Interact 2022; 6: 1\u201322.","journal-title":"Proc ACM Hum Comput Interact"},{"key":"e_1_3_4_71_2","doi-asserted-by":"publisher","DOI":"10.1145\/3678593"},{"key":"e_1_3_4_72_2","doi-asserted-by":"publisher","DOI":"10.1145\/3596240"},{"key":"e_1_3_4_73_2","doi-asserted-by":"publisher","DOI":"10.1145\/3706598.3714208"},{"key":"e_1_3_4_74_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cogsys.2024.101264"},{"key":"e_1_3_4_75_2","doi-asserted-by":"publisher","DOI":"10.1002\/cnm.3601"},{"key":"e_1_3_4_76_2","doi-asserted-by":"publisher","DOI":"10.1200\/PO.22.00518"},{"key":"e_1_3_4_77_2","first-page":"3784","article-title":"Insulin resistance prediction from wearables and routine blood biomarkers","volume":"1","author":"Metwally AA","year":"2025","unstructured":"Metwally AA, Heydari AA, McDuff D, et al. Insulin resistance prediction from wearables and routine blood biomarkers. arXiv preprint 2025; 1: 3784.","journal-title":"arXiv preprint"},{"key":"e_1_3_4_78_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40504-021-00113-x"},{"key":"e_1_3_4_79_2","doi-asserted-by":"publisher","DOI":"10.1145\/3706598.3713314"},{"key":"e_1_3_4_80_2","doi-asserted-by":"publisher","DOI":"10.2196\/69544"},{"key":"e_1_3_4_81_2","first-page":"13518","article-title":"Addressing data quality challenges in observational ambulatory studies: analysis, methodologies and practical solutions for wrist-worn wearable monitoring","volume":"1","author":"Donckt JVD","year":"2024","unstructured":"Donckt JVD, Vandenbussche N, Donckt JVD, et al. Addressing data quality challenges in observational ambulatory studies: analysis, methodologies and practical solutions for wrist-worn wearable monitoring. arXiv preprint 2024; 1: 13518.","journal-title":"arXiv preprint"},{"key":"e_1_3_4_82_2","doi-asserted-by":"publisher","DOI":"10.30574\/wjbphs.2024.20.1.0709"},{"key":"e_1_3_4_83_2","doi-asserted-by":"publisher","DOI":"10.1145\/3131892"},{"key":"e_1_3_4_84_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.esmorw.2024.100056"},{"key":"e_1_3_4_85_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41746-022-00640-7"}],"container-title":["Health Informatics Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/14604582251392455","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/14604582251392455","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/14604582251392455","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T14:05:31Z","timestamp":1762092331000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/14604582251392455"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":84,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1177\/14604582251392455"],"URL":"https:\/\/doi.org\/10.1177\/14604582251392455","relation":{},"ISSN":["1460-4582","1741-2811"],"issn-type":[{"type":"print","value":"1460-4582"},{"type":"electronic","value":"1741-2811"}],"subject":[],"published":{"date-parts":[[2025,10]]},"article-number":"14604582251392455"}}