{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:21:13Z","timestamp":1778545273435,"version":"3.51.4"},"reference-count":38,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2021,1,18]],"date-time":"2021-01-18T00:00:00Z","timestamp":1610928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Orthod"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:sec><jats:title>Background:<\/jats:title><jats:p> Different genes and loci that are associated with non-syndromic developmental tooth agenesis (TA) have the same causation pathway in the development of tumours including breast cancer (BC), epithelial ovarian cancer (EOC), colorectal cancer (CRC) and lung cancer (LC). <\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives:<\/jats:title><jats:p> To assess the link between TA and the development of cancer. <\/jats:p><\/jats:sec><jats:sec><jats:title>Search sources:<\/jats:title><jats:p> This registered review included a comprehensive search of electronic databases (Cochrane Central Register of Controlled Trials [CENTRAL], LILACS, Scopus, Web of Science and Medline via Ovid) until 1 April 2020, supplemented by manual, grey literature and reference lists search. There was no restriction in term of date of publication, gender, race or type of hypodontia. <\/jats:p><\/jats:sec><jats:sec><jats:title>Data selection:<\/jats:title><jats:p> The primary outcome was the relationship between TA and cancer. The secondary outcome was to identify the genetic correlation between TA and cancer. <\/jats:p><\/jats:sec><jats:sec><jats:title>Data extraction:<\/jats:title><jats:p> Study selection, data extraction and risk of bias assessment were performed independently and induplicate by two reviewers, with disputes resolved by a third reviewer. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> Eight studies with a moderate-high risk of bias were included in the final review, with a total of 5821 participants. Due to the heterogeneity among the included studies, the data were presented narratively. Limited studies reported a high prevalence of EOC (19.2%\u201320%) and CRC (82%\u2013100%) in individuals with TA (depending on the study) compared to those without TA (3% for EOC and 0% for CRC). While others reported a weak correlation between EOC and CRC and TA ( P &gt; 0.05). Weak evidence suggested a strong correlation between breast, cervical uterine and prostate cancers and TA ( P &lt; 0.05). <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p> Though low-quality evidence suggests a link between TA and cancer, it was not possible to verify that TA can hold a predictive value as a marker for cancers. Further research is needed to confirm the association. <\/jats:p><\/jats:sec><jats:sec><jats:title>Registration:<\/jats:title><jats:p> PROSPERO (CRD42020139751). <\/jats:p><\/jats:sec>","DOI":"10.1177\/1465312520984166","type":"journal-article","created":{"date-parts":[[2021,1,18]],"date-time":"2021-01-18T09:23:48Z","timestamp":1610961828000},"page":"221-230","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Are developmentally missing teeth a predictive risk marker of malignant diseases in non-syndromic individuals? 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