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The intravenous urogram revealed a filling defect in the urinary bladder. Cystoscopy dis closed a non-papillary tumour arising from the roof of the bladder neck. Transurethral resection was, accordingly, performed - but marked fluctuation in blood pressure was observed during the procedure. The histopathological findings of trabeculae and small nests of plump oval to spindle cells with a clear to acidophilic cytoplasm, forming an organoid pat tern and demonstrating inconspicuous mitotic activ ity, were diagnostic of paraganglioma of the urinary bladder; the diagnosis was confirmed by means of immunohistochemical and ultrastructural studies. The endocrine markers chromogranin A and neu ron-specific enolase were positive in chief cells; sus tentacular cells at the periphery of neoplastic cell clusters were positive for S-100 protein. Neurosecre tory granules were identified by electron microscop ic examination. It is emphasised that, currently, there are no anatomico-pathological criteria to distinguish benign and malignant forms of the disease. Post-sur gical recovery was uneventful in this case. Recurrence and metastases, though infrequent, have been report ed in the literature; therefore, radiation therapy may be an important adjunct - and long-term follow-up is mandatory.<\/jats:p>","DOI":"10.1177\/146642400112100317","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T13:36:39Z","timestamp":1190122599000},"page":"193-198","source":"Crossref","is-referenced-by-count":6,"title":["Lessons to be learned: a case study approach Paraganglioma of the urinary bladder"],"prefix":"10.1177","volume":"121","author":[{"given":"Madhu","family":"Dewan","sequence":"first","affiliation":[{"name":"Asir Central Hospital, Abha, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Rasshid","sequence":"additional","affiliation":[{"name":"Department of Urology, Asir Central Hospital, Abha, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elfadil Ma","family":"Elmalik","sequence":"additional","affiliation":[{"name":"Asir Central Hospital, Abha, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad Amin","family":"Ansari","sequence":"additional","affiliation":[{"name":"Laboratory Medicine, Asir Central Hospital, Abha, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nader","family":"Morad","sequence":"additional","affiliation":[{"name":"Asir Central Hospital, Abha, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2001,9]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(196905)23:5<1110::AID-CNCR2820230515>3.0.CO;2-C"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/030089168306900114"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.21.2.184"},{"issue":"8","key":"e_1_2_1_5_1","first-page":"899","article-title":"Paraganglioma of the spermatic cord: report of a case with immunohistochemical and ultrastructural studies","volume":"114","author":"Bacchi C.E.","year":"1990","unstructured":"Bacchi C.E., Schmidt R.A., Brandao M., Scapulatempo R., Costa J.C. and Schmitt F.C. 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