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This work pursues ion desorption from 13-\u00b5m activated tungsten emitters at atmospheric pressure. The emitters are positioned in front of the atmospheric pressure interface of a Fourier transform-ion cyclotron resonance (FT-ICR) mass spectrometer and the entrance electrode of the interface is set to 3\u20135 kV with respect to the emitter. Under these conditions positive, and for the first time, negative ion desorption is achieved. In either polarity, atmospheric pressure field desorption (APFD) is robust and spectra are reproducible. Both singly charged positive and negative ions formed by these processes are characterized by accurate mass-based formula assignments and in part by tandem mass spectrometry. The compounds analyzed include the ionic liquids trihexyl(tetradecyl) phosphonium tris(pentafluoroethyl) trifluorophosphate) and 1-butyl-1-methylpyrrolidinium bis(trifluoromethylsulfonyl)imide, the acidic compounds perfluorononanoic acid and polyethylene glycol diacid, as well as two amino-terminated polypropylene glycols. Some surface mobility on the emitter is prerequisite for ion desorption to occur. While ionic liquids inherently provide this mobility, the desorption of ions from solid analytes requires the assistance of a liquid matrix, e.g. glycerol.<\/jats:p>","DOI":"10.1177\/14690667221133388","type":"journal-article","created":{"date-parts":[[2022,10,18]],"date-time":"2022-10-18T03:51:12Z","timestamp":1666065072000},"page":"21-32","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Desorption of positive and negative ions from activated field emitters at atmospheric pressure"],"prefix":"10.1177","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0748-2535","authenticated-orcid":false,"given":"J\u00fcrgen H.","family":"Gross","sequence":"first","affiliation":[{"name":"Institute of Organic Chemistry, Heidelberg University, Heidelberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,10,18]]},"reference":[{"key":"bibr1-14690667221133388","volume-title":"Field-Ionization Mass Spectrometry","author":"Beckey HD","year":"1971"},{"key":"bibr2-14690667221133388","volume-title":"Principles of Field Desorption and Field Ionization Mass Spectrometry","author":"Beckey HD","year":"1977"},{"key":"bibr3-14690667221133388","first-page":"1","volume":"9","author":"Pr\u00f3kai L","year":"1990","journal-title":"Pract Spectrosc"},{"key":"bibr4-14690667221133388","doi-asserted-by":"publisher","DOI":"10.1177\/1469066720939399"},{"key":"bibr5-14690667221133388","doi-asserted-by":"publisher","DOI":"10.1002\/jms.3062"},{"key":"bibr6-14690667221133388","doi-asserted-by":"publisher","DOI":"10.1002\/jms.4254"},{"key":"bibr7-14690667221133388","doi-asserted-by":"publisher","DOI":"10.1002\/oms.1210121112"},{"key":"bibr8-14690667221133388","doi-asserted-by":"publisher","DOI":"10.1021\/ac00136a021"},{"key":"bibr9-14690667221133388","unstructured":"Linden HB. 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