{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T21:56:43Z","timestamp":1777586203027,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","issue":"5-6","license":[{"start":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T00:00:00Z","timestamp":1755734400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Eur J Mass Spectrom (Chichester)"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:p>\n                    Diabetes mellitus (DM) is an onset metabolic illness in which hyperglycemia occurs due to acquired or inherited impaired insulin production and ineffective action. Diabetes is frequently managed with the use of drugs, which may have adverse consequences even though they are good at regulating blood glucose levels. Herbal remedies are therefore being investigated as a substitute because of their reduced toxicity and fewer adverse effects. Using alloxan-induced diabetic rats, this work intends to investigate the possible anti-diabetic and anti-hyperlipidemic effects of ethanolic and aqueous leaf extracts of\n                    <jats:italic toggle=\"yes\">Celtis tetrandra<\/jats:italic>\n                    Roxb. The antidiabetic activity was tested in 35 rats with diabetes induced by a single alloxan injection (140\u2005mg\u00b7kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    ). Diabetic rats with blood glucose level (BGL &gt;180\u2005mg\/100\u2005mL) were treated with extracts (100 and 200\u2005mg\u00b7kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    ) and glibenclamide (5\u2005mg\u00b7kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    ) as a standard drug, and fasting BGL, lipid profiles, body weight, and pancreatic histopathology were assessed. The result was analyzed using SPSS software by one-way ANOVA, followed by Tukey's post hoc test, with\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.05 being a statistically reliable result. The ethanolic and aqueous leaf extracts of\n                    <jats:italic toggle=\"yes\">C. tetrandra<\/jats:italic>\n                    (100 and 200\u2005mg\u00b7kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    ) significantly reduced BGL, with the 200\u2005mg\u00b7kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    ethanolic extract showing the most notable effect at day 21st. Lipid profiles improved, and pancreatic histopathology revealed increased \u03b2-cell regeneration. The preliminary study supported the use of leaf extracts from\n                    <jats:italic toggle=\"yes\">C. tetrandra<\/jats:italic>\n                    as an herbal remedy for hyperglycemia and maintaining a normal level of lipids.\n                  <\/jats:p>","DOI":"10.1177\/14690667251370487","type":"journal-article","created":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T08:38:07Z","timestamp":1755765487000},"page":"182-188","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Antidiabetic potential of\n                    <i>Celtis tetrandra<\/i>\n                    Roxb. leaf extracts in alloxan-induced diabetic rats, lipid profile, and histopathological analysis of pancreas"],"prefix":"10.1177","volume":"31","author":[{"given":"Shumaila","family":"Yousaf","sequence":"first","affiliation":[{"name":"University of Veterinary and Animal Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sadia","family":"Nawaz","sequence":"additional","affiliation":[{"name":"University of Veterinary and Animal Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shagufta","family":"Saeed","sequence":"additional","affiliation":[{"name":"University of Veterinary and Animal Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huma","family":"Mujahid","sequence":"additional","affiliation":[{"name":"University of Veterinary and Animal Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azamt","family":"Ullah","sequence":"additional","affiliation":[{"name":"University of Veterinary and Animal Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5616-195X","authenticated-orcid":false,"given":"Duaa","family":"Qaiser","sequence":"additional","affiliation":[{"name":"University of the Punjab"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7354-328X","authenticated-orcid":false,"given":"Tahir","family":"Mehmood","sequence":"additional","affiliation":[{"name":"University of the Punjab"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,8,21]]},"reference":[{"key":"e_1_3_2_2_2","first-page":"119","article-title":"An overview of diabetes mellitus: types, complications, and management","volume":"4","author":"Amin N","year":"2018","unstructured":"Amin N. An overview of diabetes mellitus: types, complications, and management. Int J Nurs Sci Pract Res 2018; 4: 119\u2013124.","journal-title":"Int J Nurs Sci Pract Res"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2019.115263"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.3390\/biology9090252"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.201700201"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.3390\/biom9100551"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40200-020-00628-8"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/1934578X1801300412"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1080\/0972060X.2023.2223216"},{"key":"e_1_3_2_10_2","first-page":"13","article-title":"Phytochemical screening, antimicrobial and antioxidant activities of Celtis integrifolia (Lam) leaves","volume":"4","author":"Sa\u2019id AI","year":"2021","unstructured":"Sa\u2019id AI, Abba HM. Phytochemical screening, antimicrobial and antioxidant activities of Celtis integrifolia (Lam) leaves. Int J Sci Res Eng Dev 2021; 4: 13\u201321.","journal-title":"Int J Sci Res Eng Dev"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0367-326X(02)00118-1"},{"key":"e_1_3_2_12_2","first-page":"1294","article-title":"Hypoglycemic and hypolipidemic effect of Celtis philippensis Blanco on Albino Wistar rats","volume":"9","author":"Thomas S","year":"2022","unstructured":"Thomas S, Kumar Y. Hypoglycemic and hypolipidemic effect of Celtis philippensis Blanco on Albino Wistar rats. 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Hypoglycaemic and hypolipidaemic potential of aerial parts of Amaranthus viridis (L.) Merr. in streptozotocin induced diabetic rats. Int J Pharm Arch 2012; 1: 1\u20136.","journal-title":"Int J Pharm Arch"},{"key":"e_1_3_2_17_2","first-page":"189","article-title":"Effect of T. arjuna stem bark extract on histopathology of liver, kidney and pancreas of alloxan-induced diabetic rats","volume":"9","author":"Ragavan B","year":"2006","unstructured":"Ragavan B, Krishnakumari S. Effect of T. arjuna stem bark extract on histopathology of liver, kidney and pancreas of alloxan-induced diabetic rats. Afr J Biomed Res 2006; 9: 189\u2013197.","journal-title":"Afr J Biomed Res"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1177\/14690667251346782"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2020.113178"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2022.987552"},{"key":"e_1_3_2_21_2","first-page":"512","article-title":"Isolation and identification of catechin from Dioscorea bulbifera L. tubers and screening on hypoglycemic activity","volume":"18","author":"Cho K","year":"2020","unstructured":"Cho K, Win YY, Aye HH, et al. Isolation and identification of catechin from Dioscorea bulbifera L. tubers and screening on hypoglycemic activity. J Myanmar Acad Arts Sci 2020; 18: 512\u2013521.","journal-title":"J Myanmar Acad Arts Sci"},{"key":"e_1_3_2_22_2","first-page":"4","volume-title":"Antihyperglycemic and pancreatic protective effect of squalene in streptozotocin-induced diabetic ratProceedings of the 3rd international conference of computer, environment, agriculture, social science, health science, engineering and technology (ICEST 2018)","author":"Widyawati T","unstructured":"Widyawati T, Syarifah S, Ichwan M, et al. Antihyperglycemic and pancreatic protective effect of squalene in streptozotocin-induced diabetic rat. 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