{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T20:34:23Z","timestamp":1793133263045,"version":"4.5.0"},"reference-count":22,"publisher":"SAGE Publications","issue":"5-6","license":[{"start":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T00:00:00Z","timestamp":1776038400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Eur J Mass Spectrom (Chichester)"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:p>\n                    Diabetes mellitus continues to be a significant worldwide health burden, necessitating safe and efficient treatment alternatives. In alloxan-induced diabetic rats, this study examined the combined antidiabetic effectiveness of chromium picolinate and\n                    <jats:italic toggle=\"yes\">Prunus persica<\/jats:italic>\n                    kernel extract. Gas chromatography\/mass spectrometry was used to phytochemically characterize a polyphenolic-rich extract (60% acetone). Alloxan monohydrate (140\u2005mg\/kg b.w.) was administered intraperitoneally to develop diabetes in rats. The animals were split into groups for normal control, diabetic control, chromium picolinate, Prunus kernel extract, three combination therapy groups, and conventional medication. The treatments were administered orally on a 21-day basis. Insulin levels in serum were also measured following dissection, and body weight and fasting blood glucose (FBG) were monitored prior to and after treatment. Pancreatic tissue was taken in order to determine the preservation and regeneration of B-cells through a histological analysis. Compared to individual therapy, the combined therapy had a significant benefit of reducing the level of FBG (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u2009.01), increasing serum insulin significantly, and rescuing the morphology of the pancreatic B-cells. These findings confirm the\n                    <jats:italic toggle=\"yes\">P. persica<\/jats:italic>\n                    kernel extracts and chromium picolinate as supplementation therapies in diabetes management because they suggest that the two compounds act synergistically to enhance pancreatic protection and control glucose levels.\n                  <\/jats:p>","DOI":"10.1177\/14690667261438360","type":"journal-article","created":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T13:43:38Z","timestamp":1776087818000},"page":"130-139","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Synergistic antidiabetic effects of GC-MS profiled\n                    <i>Prunus persica<\/i>\n                    kernel extract and chromium picolinate in alloxan-induced diabetic rats"],"prefix":"10.1177","volume":"32","author":[{"given":"Fiza","family":"Shahid","sequence":"first","affiliation":[{"name":"University of Veterinary & Animal Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shagufta","family":"Saeed","sequence":"additional","affiliation":[{"name":"University of Veterinary & Animal Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huma","family":"Mujhaid","sequence":"additional","affiliation":[{"name":"University of Veterinary & Animal Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waqas","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Food Science and Human Nutrition, University of Veterinary and Animal Sciences, Lahore, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quratulain","family":"Maqsood","sequence":"additional","affiliation":[{"name":"University of the Punjab"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hifza","family":"Rahat","sequence":"additional","affiliation":[{"name":"University of the Punjab"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7354-328X","authenticated-orcid":false,"given":"Tahir","family":"Mehmood","sequence":"additional","affiliation":[{"name":"University of the Punjab"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,4,13]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.56808\/2985-1130.3164"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amsu.2022.103901"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41438-019-0140-8"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.4103\/1735-5362.323917"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1080\/87559129.2020.1837861"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11130-018-0688-8"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu11092176"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fbio.2023.102914"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1055\/a-0955-5876"},{"key":"e_1_3_2_11_2","first-page":"1","article-title":"The anti-proliferative effect of apricot and peach kernel extracts on human colon cancer cells in vitro","volume":"19","author":"Cassiem W","year":"2019","unstructured":"Cassiem W, de Kock M. The anti-proliferative effect of apricot and peach kernel extracts on human colon cancer cells in vitro. BMC Complement Med Ther 2019; 19: 1\u201312.","journal-title":"BMC Complement Med Ther"},{"key":"e_1_3_2_12_2","first-page":"387","article-title":"Effect of antioxidants and cytotoxic activities of apricot (Prunus Armeniaca L.) and peach (Prunus Persica L.). Kernels Extracts on Experimental Rats","volume":"2023","author":"Esraa Fadl MHH","year":"2023","unstructured":"Esraa Fadl MHH, El-Mehiry HF, El-Sayed A, et al. Effect of antioxidants and cytotoxic activities of apricot (Prunus Armeniaca L.) and peach (Prunus Persica L.). Kernels Extracts on Experimental Rats. Res J Spec Educ 2023; 2023: 387\u2013411.","journal-title":"Res J Spec Educ"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-2863(02)00220-6"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.2174\/187152612804142215"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu12061864"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10653-024-02297-5"},{"key":"e_1_3_2_17_2","first-page":"427","article-title":"Antihyperglycaemic activities of plant-extracted succinic acid and hexamethylcyclotrisiloxane in diabetic albino rats","volume":"11","author":"Opara CE","year":"2024","unstructured":"Opara CE, Iwuji SC, Onyebuagu PC, et al. Antihyperglycaemic activities of plant-extracted succinic acid and hexamethylcyclotrisiloxane in diabetic albino rats. Eur J Med Sci 2024; 11: 427\u2013433.","journal-title":"Eur J Med Sci"},{"key":"e_1_3_2_18_2","first-page":"492","article-title":"Antidiabetic effect of aqueous extract of Medicago Sativa with enhanced histopathology of pancreas in alloxan induced diabetic rats","volume":"15","author":"Khalaf SJ","year":"2021","unstructured":"Khalaf SJ, Aljader GH, Sarhat ER, et al. Antidiabetic effect of aqueous extract of Medicago Sativa with enhanced histopathology of pancreas in alloxan induced diabetic rats. Pak J Med Health Sci 2021; 15: 492\u2013496.","journal-title":"Pak J Med Health Sci"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0238727"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1155\/tswj\/5648662"},{"key":"e_1_3_2_21_2","first-page":"499","article-title":"Anti-Hyperglycemic and antioxidant effect of peach (Prunus Persica L.)","volume":"12","author":"Morsi RM","year":"2022","unstructured":"Morsi RM. Anti-Hyperglycemic and antioxidant effect of peach (Prunus Persica L.). Seed Extract. Middle East J Appl Sci 2022; 12: 499\u2013514.","journal-title":"Seed Extract. Middle East J Appl Sci"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtemb.2023.127338"},{"key":"e_1_3_2_23_2","first-page":"2032","article-title":"Essential oil extracted from peach (Prunus persica) kernel and its physicochemical and antioxidant properties","volume":"44","author":"Wu H","year":"2011","unstructured":"Wu H, Shi J, Xue S, et al. Essential oil extracted from peach (Prunus persica) kernel and its physicochemical and antioxidant properties. Food Sci Technol 2011; 44: 2032\u20132039.","journal-title":"Food Sci Technol"}],"container-title":["European Journal of Mass Spectrometry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/14690667261438360","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/14690667261438360","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/14690667261438360","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T20:19:39Z","timestamp":1793132379000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/14690667261438360"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,13]]},"references-count":22,"journal-issue":{"issue":"5-6","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1177\/14690667261438360"],"URL":"https:\/\/doi.org\/10.1177\/14690667261438360","relation":{},"ISSN":["1469-0667","1751-6838"],"issn-type":[{"value":"1469-0667","type":"print"},{"value":"1751-6838","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,13]]}}}