{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T01:58:22Z","timestamp":1777859902274,"version":"3.51.4"},"reference-count":37,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2009,6,1]],"date-time":"2009-06-01T00:00:00Z","timestamp":1243814400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Renin Angiotensin Aldosterone Syst"],"published-print":{"date-parts":[[2009,6]]},"abstract":"<jats:p>Introduction. Angiotensin-converting enzyme inhibitors prevent atrial fibrillation episodes by effective control of blood pressure and improving electrical and structural remodelling in the atria. Increased P wave dispersion (PWD) is a non-invasive electrocardiographic marker for paroxysmal atrial fibrillation. The aim of the study was to evaluate the effect of perindopril treatment on PWD in hypertensive patients. Methods. Forty-eight hypertensive patients (mean age 57.4\u00b111.8 years, 18 men) were included. Blood pressure values were determined and 12-lead electrocardiograms were recorded at the beginning and at the first week, first month, third month and sixth month of the perindopril treatment.The difference between maximum and minimum P wave durations was calculated as PWD.<\/jats:p>\n                  <jats:p>Results. PWDs were significantly shortened at the first, third and sixth months (41.7\u00b18.8 ms, 39.1\u00b16.9 ms and 38.3\u00b17.1 ms, respectively) compared with baseline and first-week measurements (54.3\u00b19.2 ms and 49.0\u00b19.1 ms, respectively, p&lt;0.001). Baseline PWD was correlated with body mass index (r=0.32, p=0.026), while PWD at the sixth month of treatment was significantly correlated with left atrial volume index (r=0.30, p=0.042). Multiple linear regression analysis revealed that PWD at the sixth month was related to baseline PWD (p=0.001).<\/jats:p>\n                  <jats:p>Conclusion. Perindopril treatment significantly reduced PWD in hypertensive patients.<\/jats:p>","DOI":"10.1177\/1470320309105199","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T05:23:06Z","timestamp":1244179386000},"page":"85-90","source":"Crossref","is-referenced-by-count":2,"title":["Perindopril decreases P wave dispersion in patients with stage 1 hypertension"],"prefix":"10.1177","volume":"10","author":[{"given":"Beste","family":"Ozben","sequence":"first","affiliation":[{"name":"Department of Cardiology, Marmara University Faculty of Medicine, Istanbul, Turkey,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mutlu","family":"Sumerkan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Marmara University Faculty of Medicine, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azra Meryem","family":"Tanrikulu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Marmara University Faculty of Medicine, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nurdan","family":"Papila-Topal","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Marmara University Faculty of Medicine, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali Serdar","family":"Fak","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Marmara University Faculty of Medicine, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmet","family":"Toprak","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Marmara University Faculty of Medicine, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2009,6,5]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.18.2370"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(02)01236-6"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(02)01253-6"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(99)80348-9"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(98)00583-9"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(03)00227-3"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000052830.02773.E4"},{"key":"atypb8","first-page":"38","volume":"145","author":"Geller JC","year":"2003","journal-title":"MMW Fortschr Med"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(98)70030-4"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.2000.tb06761.x"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(00)01056-0"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1023\/A:1016368723033"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1002\/clc.4960280609"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1994.03510350050036"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.1998.tb00114.x"},{"key":"atypb16","first-page":"21","volume":"20","author":"Nattel S.","year":"2005","journal-title":"Curr Opin Cardiol"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.22.2612"},{"key":"atypb18","doi-asserted-by":"crossref","unstructured":"Li D, Shinagawa K, Pang L et al. Effects of angiotensin-converting enzyme inhibition on the development of the atrial fibrillation substrate in dogs with ventricular tachypacinginduced congestive heart failure. Circulation 2001;104:2608-14. 19. Klein HU, Goette A. Blockade of atrial angiotensin II type 1 receptors: a novel antiarrhythmic strategy to prevent atrial fibrillation? 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