{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:13:25Z","timestamp":1787019205622,"version":"build-2736575974"},"reference-count":45,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2009,10,27]],"date-time":"2009-10-27T00:00:00Z","timestamp":1256601600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Renin Angiotensin Aldosterone Syst"],"published-print":{"date-parts":[[2010,3]]},"abstract":"<jats:p>\n                    Recent knowledge demonstrated that the renin-angiotensin system (RAS) functions as a local renal paracrine system. All components of the RAS are present within the kidney and include angiotensinogen, renin, angiotensin I, angiotensin-converting enzymes, angiotensin II, the angiotensin II type 1 (AT\n                    <jats:sub>1<\/jats:sub>\n                    ) receptor and the angiotensin II type 2 (AT\n                    <jats:sub>2<\/jats:sub>\n                    ) receptor. Angiotensin II is the major effector hormone of the RAS and contributes to a variety of renal and cardiovascular physiologic and pathologic mechanisms through stimulation of AT\n                    <jats:sub>1<\/jats:sub>\n                    and AT\n                    <jats:sub>2<\/jats:sub>\n                    receptors. Angiotensin receptor blockers were developed based on the advanced knowledge of the AT\n                    <jats:sub>1<\/jats:sub>\n                    receptor contribution to development of a variety of kidney, vascular and cardiac diseases including but not limited to hypertension, diabetic nephropathy, heart failure, myocardial infarction and atherosclerosis. In contrast, knowledge concerning the role of the AT\n                    <jats:sub>2<\/jats:sub>\n                    receptor in health and disease is still emerging. The AT\n                    <jats:sub>2<\/jats:sub>\n                    receptor is believed to counterbalance the effects of the AT\n                    <jats:sub>1<\/jats:sub>\n                    receptor through influencing cellular differentiation, vasodilation, inhibition of cellular proliferation and hypertrophy, nitric oxide production and natriuresis. Thus, the pursuit of a specific AT\n                    <jats:sub>2<\/jats:sub>\n                    receptor agonist is a potentially fruitful area for combating renal and cardiovascular diseases. This review focuses on the role of the AT\n                    <jats:sub>2<\/jats:sub>\n                    receptor in the kidney.\n                  <\/jats:p>","DOI":"10.1177\/1470320309347786","type":"journal-article","created":{"date-parts":[[2009,10,27]],"date-time":"2009-10-27T20:44:23Z","timestamp":1256676263000},"page":"33-36","source":"Crossref","is-referenced-by-count":44,"title":["The angiotensin II type 2 receptor and the kidney"],"prefix":"10.1177","volume":"11","author":[{"given":"Helmy M","family":"Siragy","sequence":"first","affiliation":[{"name":"Hypertension Centre, University of Virginia, Charlottesville, Virginia, USA,"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2009,10,27]]},"reference":[{"key":"atypb1","first-page":"271","volume":"2","author":"Lazard D.","year":"1994","journal-title":"Receptors Channels"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)74498-6"},{"key":"atypb3","first-page":"H2332","volume":"281","author":"Berry C.","year":"2001","journal-title":"Am J Physiol"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.87.9.753"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.33.2.613"},{"key":"atypb6","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/S0031-6997(24)01458-3","volume":"52","author":"De Gasparo M.","year":"2000","journal-title":"Pharmacol Rev"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.35.1.155"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0705448"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.23.10663"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(98)00267-3"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1159\/000045121"},{"key":"atypb12","first-page":"F437","volume":"277","author":"Miyata N.","year":"1999","journal-title":"Am J Physiol"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.30.5.1238"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1996.0558u.x"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.77.6.1070"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-200208000-00025"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.2001.280.2.F254"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2826.2008.01646.x"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118630"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119531"},{"key":"atypb21","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1996.271.4.R1090"},{"key":"atypb22","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.33.5.1237"},{"key":"atypb23","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.35.5.1074"},{"key":"atypb24","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.33.1.96"},{"key":"atypb25","doi-asserted-by":"publisher","DOI":"10.1038\/377744a0"},{"key":"atypb26","doi-asserted-by":"publisher","DOI":"10.1038\/377748a0"},{"key":"atypb27","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.11.6506"},{"key":"atypb28","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1999.1027"},{"key":"atypb29","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1999.0500"},{"key":"atypb30","doi-asserted-by":"crossref","unstructured":"Tsutsumi Y, Matsubara H, Masaki H et al. Angiotensin II type 2 receptor overexpression activates the vascular kinin system and causes vaso-dilation. J Clin Invest 1999;104:925-35. 31. Barber MN, Sampey DB, Widdop RE. AT2 receptor stimulation enhances antihypertensive effect of AT1 receptor antagonist in hypertensive rats. Hypertension 1999;34:1112-16.","DOI":"10.1161\/01.HYP.34.5.1112"},{"key":"atypb31","doi-asserted-by":"publisher","DOI":"10.1161\/hy1201.096576"},{"key":"atypb32","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000149105.75125.2a"},{"key":"atypb33","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00014.2007"},{"issue":"11","key":"atypb34","first-page":"S69","volume":"10","author":"Haithcock D.","year":"1999","journal-title":"J Am Soc Nephrol"},{"key":"atypb35","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.38.3.309"},{"key":"atypb36","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117792"},{"key":"atypb37","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000043904.26730.11"},{"key":"atypb38","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00218.2005"},{"key":"atypb39","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2000.00820.x"},{"key":"atypb40","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000220112.91724.fc"},{"key":"atypb41","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000123574.60586.7d"},{"key":"atypb42","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.107.092973"},{"key":"atypb43","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000196950.48596.21"},{"key":"atypb44","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.107.103242"},{"key":"atypb45","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000251881.89610.ee"}],"container-title":["Journal of the Renin-Angiotensin-Aldosterone System"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1470320309347786","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1470320309347786","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:39:44Z","timestamp":1777509584000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1470320309347786"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,10,27]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,3]]}},"alternative-id":["10.1177\/1470320309347786"],"URL":"https:\/\/doi.org\/10.1177\/1470320309347786","relation":{},"ISSN":["1470-3203","1752-8976"],"issn-type":[{"value":"1470-3203","type":"print"},{"value":"1752-8976","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,10,27]]}}}