{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T16:27:01Z","timestamp":1792168021111,"version":"4.4.0"},"reference-count":38,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2011,3,10]],"date-time":"2011-03-10T00:00:00Z","timestamp":1299715200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Renin Angiotensin Aldosterone Syst"],"published-print":{"date-parts":[[2011,9]]},"abstract":"<jats:p>Introduction: We assessed the additional effects of eplerenone to angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin II receptor blockers (ARBs) on 24-h blood pressure (BP) level, fibrinolytic activity, and cardiovascular protection in elderly (&gt;60 years) hypertensive patients.<\/jats:p>\n                  <jats:p>Materials and methods: In total, 20 patients (mean age 74 years, 25% men), whose BP was uncontrolled despite the use of anti-hypertensive drugs including ACEIs or ARBs (average 2.4 drugs), received eplerenone once daily (mean 37.5 mg) for 24 weeks.<\/jats:p>\n                  <jats:p>Results: Eplerenone treatment significantly reduced mean 24-h systolic\/diastolic BP levels (143\/80 mmHg to 132\/74 mmHg, both p &lt; 0.002). The reduction of 24-h systolic BP levels, especially night-time BP, was significantly associated with the reduction of atrial natriuretic peptide and brain natriuretic peptide levels (all p &lt; 0.05). Furthermore, after eplerenone treatment, the mean plasminogen activator inhibitor-1 antigen level was significantly reduced (35 ng\/ml to 25 ng\/ml, p &lt; 0.05), and the median level of plasma procollagen type III aminoterminal peptide and the urinary albumin excretion rate were also significantly reduced (0.8 U\/ml to 0.6 U\/ml, p &lt; 0.003 and 53 mg\/g\u00b7Cr to 23 mg\/g\u00b7Cr, p &lt; 0.05, respectively). During the intervention, eplerenone treatment was well tolerated with no reports of hyperkalaemia or hypotension.<\/jats:p>\n                  <jats:p>Conclusions: Addition of eplerenone to ACEIs or ARBs in elderly hypertensive patients offers significant benefits in terms of 24-h BP levels, fibrinolysis, and cardiovascular protection.<\/jats:p>","DOI":"10.1177\/1470320310390404","type":"journal-article","created":{"date-parts":[[2011,3,10]],"date-time":"2011-03-10T21:52:32Z","timestamp":1299793952000},"page":"340-347","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":27,"title":["Efficacy of eplerenone added to renin-angiotensin blockade in elderly hypertensive patients: the Jichi-Eplerenone Treatment (JET) study"],"prefix":"10.1177","volume":"12","author":[{"given":"Yuichiro","family":"Yano","sequence":"first","affiliation":[{"name":"Division of Internal Medicine, Saigo National Health Insurance Hospital, Miyazaki, Japan, , Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, Tochigi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Hoshide","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, Tochigi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noboru","family":"Tamaki","sequence":"additional","affiliation":[{"name":"Tamaki Clinic, Miyazaki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiko","family":"Nagata","sequence":"additional","affiliation":[{"name":"Kijo Clinic, Miyazaki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kouji","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Sasaki Clinic, Miyazaki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshimasa","family":"Kanemaru","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine, Saigo National Health Insurance Hospital, Miyazaki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuyuki","family":"Shimada","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, Tochigi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuomi","family":"Kario","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, Tochigi, 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