{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:15:02Z","timestamp":1791306902193,"version":"4.3.1"},"reference-count":34,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2012,1,25]],"date-time":"2012-01-25T00:00:00Z","timestamp":1327449600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Renin Angiotensin Aldosterone Syst"],"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:p>Introduction: To explore whether the insertion (I) and deletion (D) polymorphism of angiotensin-converting enzyme ( ACE) confers susceptibility to vasculitis.<\/jats:p>\n                  <jats:p>Materials and methods: A meta-analysis was conducted on the associations between the ACE I\/D polymorphism and vasculitis.<\/jats:p>\n                  <jats:p>\n                    Results: Twelve studies, including four on Beh\u00e7et\u2019s disease (BD), four on Henoch\u2013Schenlein purpura (HSP), three on Kawasaki disease (KD), and one on Wegener\u2019s granulomatosis, were available for the meta-analysis. Meta-analysis showed that the DD + ID genotype was associated with susceptibility to vasculitis (odds ratio [OR] 1.468, 95% confidence interval [CI] 1.214\u20131.468, p = 7.4 \u00d7 10\n                    <jats:sup>\u22125<\/jats:sup>\n                    ). The overall OR for the D allele was significantly increased in BD (OR 1.313, 95% CI 1.017\u20131.695). Meta-analysis of the DD+ID genotype, the DD genotype and the DD vs. II genotype showed marginal associations with BD, but meta-analysis of the D allele, and the DD+ID genotype showed significant associations with HSP (OR 1.446, 95% CI 1.021\u20132.049, p = 0.038; OR 1.881, 95% CI 1.385\u20132.595, p = 6.6 \u00d7 10\n                    <jats:sup>\u22125<\/jats:sup>\n                    ). On the other hand, meta-analysis showed no association between KD and the ACE I\/D polymorphism.\n                  <\/jats:p>\n                  <jats:p>Conclusions: This meta-analysis shows that the ACE I\/D polymorphism is associated with vasculitis susceptibility, especially in BD and HSP.<\/jats:p>","DOI":"10.1177\/1470320311434240","type":"journal-article","created":{"date-parts":[[2012,1,25]],"date-time":"2012-01-25T22:37:07Z","timestamp":1327531027000},"page":"196-201","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":19,"title":["Associations between the angiotensin-converting enzyme insertion\/deletion polymorphism and susceptibility to vasculitis: a meta-analysis"],"prefix":"10.1177","volume":"13","author":[{"given":"Young Ho","family":"Lee","sequence":"first","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Jae","family":"Choi","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Dae","family":"Ji","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gwan Gyu","family":"Song","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, Korea University College of Medicine, Seoul, 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