{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T18:53:29Z","timestamp":1784055209190,"version":"3.55.0"},"reference-count":37,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2012,2,17]],"date-time":"2012-02-17T00:00:00Z","timestamp":1329436800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Renin Angiotensin Aldosterone Syst"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:sec>\n                    <jats:title>Hypothesis:<\/jats:title>\n                    <jats:p>This study was designed to investigate the cardio-renal protective effect of AVE-0991, a non-peptide Mas-receptor agonist, and A-779, a Mas-receptor antagonist, in diabetic rats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods:<\/jats:title>\n                    <jats:p>\n                      Wistar rats treated with streptozotocin (50 mg\/kg, i.p., once), developed diabetes mellitus after 1 week. After 8 weeks, myocardial functions were assessed by measuring left ventricular developed pressure (LVDP), rate of left ventricular pressure development (d p\/d t\n                      <jats:sub>max<\/jats:sub>\n                      ), rate of left ventricular pressure decay (d p\/d t\n                      <jats:sub>min<\/jats:sub>\n                      ) and left ventricular end diastolic pressure (LVEDP) on an isolated Langendorff\u2019s heart preparation. Further, mean arterial blood pressure (MABP) was measured by using the tail-cuff method. Assessment of renal functions and lipid profile was carried out using a spectrophotometer.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The administration of streptozotocin to rats produced persistent hyperglycaemia, dyslipidaemia and hypertension which consequently produced cardiac and renal dysfunction in 8 weeks. AVE0991 treatment produced cardio-renal protective effects, as evidenced by a significant increase in LVDP, d p\/d t\n                      <jats:sub>max<\/jats:sub>\n                      , d p\/d t\n                      <jats:sub>min<\/jats:sub>\n                      and a significant decrease in LVEDP, BUN, and protein urea. Further, AVE-0991 treatment for the first time has been shown to reduce dyslipidaemia and produced antihyperglycaemic activity in streptozotocin-treated rats. However, MABP and creatinine clearance remained unaffected with AVE-0991 treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>AVE-0991 produced cardio-renal protection possibly by improving glucose and lipid metabolism in diabetic rats, independent of its blood pressure lowering action.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1470320311435534","type":"journal-article","created":{"date-parts":[[2012,2,17]],"date-time":"2012-02-17T20:56:40Z","timestamp":1329512200000},"page":"334-340","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":25,"title":["Possible mechanism of the cardio-renal protective effects of AVE-0991, a non-peptide Mas-receptor agonist, in diabetic rats"],"prefix":"10.1177","volume":"13","author":[{"given":"Kulwinder","family":"Singh","sequence":"first","affiliation":[{"name":"ISF College of Pharmacy, Moga, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuldeepak","family":"Sharma","sequence":"additional","affiliation":[{"name":"ISF College of Pharmacy, Moga, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manjeet","family":"Singh","sequence":"additional","affiliation":[{"name":"ISF College of Pharmacy, Moga, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PL","family":"Sharma","sequence":"additional","affiliation":[{"name":"ISF College of Pharmacy, Moga, 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