{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:17:22Z","timestamp":1790615842338,"version":"4.1.0"},"reference-count":46,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2012,10,17]],"date-time":"2012-10-17T00:00:00Z","timestamp":1350432000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Renin Angiotensin Aldosterone Syst"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:sec>\n                    <jats:title>Hypothesis:<\/jats:title>\n                    <jats:p>This study aimed to elucidate the role of glibenclamide in the prevention of diabetic nephropathy and to compare it with a reference drug captopril in rats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods:<\/jats:title>\n                    <jats:p>There were two main groups of rats. Control group (I) was subdivided into four subgroups which received distilled water, vehicle of streptozotocin, glibenclamide or captopril. The streptozotocin-diabetic Group (II) was subdivided into three subgroups: untreated, glibenclamide or captopril treated. Measurement of arterial blood pressure, serum glucose and creatinine levels, 24 h urinary protein and albumin\/creatinine ratio, kidney weight and its histological examination were done after 1, 2, 4, 8, 12 and 16 weeks of treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>In treated diabetic rats captopril reduced blood pressure significantly, while no significant change in the mean arterial blood pressure or blood glucose level was recorded with glibenclamide treatment. Glibenclamide and captopril-treated diabetic rats showed significant decrease in serum creatinine level, urine volume, urinary protein excretion, albumin:creatinine ratio and kidney:body weight ratio compared with the diabetic non-treated group. Histological examination of diabetic kidneys treated with either glibenclamide or captopril showed reduced glomerular hypertrophy, glomerulosclerosis, tubular degeneration and interstitial fibrosis compared with untreated diabetic rats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Glibenclamide attenuated some biochemical and histological changes produced by diabetic nephropathy, despite persistent hyperglycemia and hypertension.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1470320312460881","type":"journal-article","created":{"date-parts":[[2012,10,18]],"date-time":"2012-10-18T12:53:07Z","timestamp":1350564787000},"page":"103-115","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Comparison between the effect of glibenclamide and captopril on experimentally induced diabetic nephropathy in rats"],"prefix":"10.1177","volume":"14","author":[{"given":"Daad H","family":"Akbar","sequence":"first","affiliation":[{"name":"Internal Medicine Department, Faculty of Medicine, King Abdulaziz, University, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magda M","family":"Hagras","sequence":"additional","affiliation":[{"name":"Pharmacology Department, Faculty of Medicine, King Abdulaziz University, Saudi Arabia"},{"name":"Pharmacology Department, Faculty of Medicine, Suez Canal University, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanan A","family":"Amin","sequence":"additional","affiliation":[{"name":"Anatomy Department, Faculty of Medicine, King Abdulaziz, University, Saudi Arabia"},{"name":"Histology Department, Faculty of Medicine, Cairo University, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omayma A","family":"Khorshid","sequence":"additional","affiliation":[{"name":"Pharmacology 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