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Acetone drop, von Frey hair, pin-prick and hot plate tests were performed to assess cold allodynia, mechanical allodynia, mechanical and heat hyperalgesia, respectively. The levels of Tumor necrosis factor-alpha (TNF-\u03b1) were measured in the sciatic nerve as an inflammatory marker. CCI was associated with the development of cold allodynia, mechanical allodynia, mechanical and heat hyperalgesia along with a rise in the levels of Tumor necrosis factor-alpha (TNF-\u03b1). Administration of aliskiren (25 or 50 mg\/kg intraperitoneal (i.p.)) for 14 days in CCI-subjected rats significantly attenuated CCI-induced pain-related behavior and rise in TNF-\u03b1 level. It may be concluded that aliskiren-mediated anti-inflammatory actions may be responsible for its beneficial effects in neuropathic pain in rats.<\/jats:p>","DOI":"10.1177\/1470320312460899","type":"journal-article","created":{"date-parts":[[2012,10,20]],"date-time":"2012-10-20T20:24:48Z","timestamp":1350764688000},"page":"116-123","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":25,"title":["Neuropathic pain-attenuating potential of aliskiren in chronic constriction injury model in rats"],"prefix":"10.1177","volume":"14","author":[{"given":"Ankesh","family":"Kukkar","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences and Drug Research, Punjabi University, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nirmal","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences and Drug Research, Punjabi University, 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