{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T01:57:12Z","timestamp":1777859832118,"version":"3.51.4"},"reference-count":16,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2012,11,23]],"date-time":"2012-11-23T00:00:00Z","timestamp":1353628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Renin Angiotensin Aldosterone Syst"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The rate-limiting step of the renin\u2013angiotensin system is the enzymatic cleavage of angiotensinogen (AGT) by renin. The aims of the present study were to investigate the association between AGT T704C (M235T) and \u2212217 G\u2192A polymorphisms with the risk of preeclampsia and synergistic effects of both polymorphisms on the susceptibility to preeclampsia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We studied AGT variants in 170 women with preeclampsia, including 84 women with mild and 86 women with severe forms of preeclampsia, and 100 age and parity matched controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>There was a trend towards increased risk of severe preeclampsia in the presence of \u2212217 AA (odds ratio (OR)=1.5, 95% confidence interval (CI)= 0.38\u20135.84, p=0.57) and TC+CC genotypes (OR=1.32, 95% CI= 0.67\u20132.58, p=0.42). However, the interaction of both alleles of \u2212217A and 704C highly increased the risk of severe preeclampsia, by 2.23-fold, although this did not reach statistical significance. The frequency of the CC genotype of the T704C polymorphism in early-onset preeclampsia tended to be higher (35%) compared with that in patients with late-onset preeclampsia (21.7%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The present study demonstrates that both variants of AGT \u2212217 G\u2192A and T704C might work in synergism to influence the risk of severe preeclampsia, which needs to be confirmed in studies with larger sample size.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1470320312467555","type":"journal-article","created":{"date-parts":[[2012,11,23]],"date-time":"2012-11-23T22:46:26Z","timestamp":1353710786000},"page":"156-161","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Synergistic effects of angiotensinogen \u2212217 G\u2192A and T704C (M235T) variants on the risk of severe preeclampsia"],"prefix":"10.1177","volume":"15","author":[{"given":"Farhad","family":"Shahvaisizadeh","sequence":"first","affiliation":[{"name":"Department of Medical Genetics, Medical School, Shahid Beheshti University of Medical Sciences, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abolfazl","family":"Movafagh","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, Medical School, Shahid Beheshti University of Medical Sciences, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mir Davood","family":"Omrani","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, Medical School, Shahid Beheshti University of Medical Sciences, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asad","family":"Vaisi-Raygani","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Medical School, Kermanshah University of Medical Sciences, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziba","family":"Rahimi","sequence":"additional","affiliation":[{"name":"Medical Biology Research Center, Kermanshah University of Medical Sciences, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zohreh","family":"Rahimi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Medical School, Kermanshah University of Medical Sciences, Iran"},{"name":"Medical Biology Research Center, Kermanshah University of Medical Sciences, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,11,23]]},"reference":[{"key":"bibr1-1470320312467555","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2004.01.035"},{"key":"bibr2-1470320312467555","doi-asserted-by":"publisher","DOI":"10.1111\/j.0001-6349.2005.00724.x"},{"key":"bibr3-1470320312467555","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000254350.62876.b1"},{"key":"bibr4-1470320312467555","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.2010.01523.x"},{"key":"bibr5-1470320312467555","doi-asserted-by":"publisher","DOI":"10.1038\/ng0593-59"},{"key":"bibr6-1470320312467555","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19990917)86:3<232::AID-AJMG7>3.0.CO;2-2"},{"key":"bibr7-1470320312467555","doi-asserted-by":"publisher","DOI":"10.1159\/000146084"},{"key":"bibr8-1470320312467555","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-200405000-00016"},{"key":"bibr9-1470320312467555","doi-asserted-by":"publisher","DOI":"10.1177\/1933719108316984"},{"key":"bibr10-1470320312467555","author":"Rahimi Z","journal-title":"J Renin Angiotensin Aldosterone Syst"},{"key":"bibr11-1470320312467555","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2008.07.048"},{"key":"bibr12-1470320312467555","first-page":"74","volume-title":"Methods in hematology, vol. 6. 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