{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T01:57:25Z","timestamp":1777859845145,"version":"3.51.4"},"reference-count":66,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T00:00:00Z","timestamp":1365033600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Renin Angiotensin Aldosterone Syst"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:sec>\n                    <jats:title>Hypothesis:<\/jats:title>\n                    <jats:p>Cardiac hypertrophy in myocytes is in part regulated by changes in expression of a novel Ang II type 2 receptor (AT2-receptor) interacting protein identified as ATIP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>The role of the AT2-receptor in cardiac hypertrophy is controversial, with some reports indicating that AT2-receptor activation has detrimental effects on disease progression, whereas others indicate that it has a beneficial role.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods:<\/jats:title>\n                    <jats:p>In an effort to unravel this paradox, we examined the expression and function of ATIP in cell-based models of cardiac hypertrophy using QPCR, immunohistochemistry, cell proliferation, morphological and transfection techniques in H9c2 cardio-myoblast and myotubules.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>These studies indicate that in cultured cardio-myoblast and myotubules, Ang II mediates cellular hypertrophy and proliferation solely via the AT1-receptor, the ATIP variants are abundantly expressed and that ATIP3 may play an anti-proliferative\/hypertrophic role in these cells in the absence of AT2-receptor expression or activation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Previously ATIP has been shown to inhibit growth factor signalling in cancerous cells via an interaction with the AT2-receptor. This is the first report to identify that ATIP may have a similar role in other disease states characterised by excessive growth and indicates that for ATIP3, at least, an interaction with the AT2-receptor may not be necessary.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1470320313483845","type":"journal-article","created":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T23:59:57Z","timestamp":1365119997000},"page":"79-91","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Function and expression of ATIP and its variants in cardiomyoblast cell line H9c2"],"prefix":"10.1177","volume":"16","author":[{"given":"Naghmeh","family":"Varghayee","sequence":"first","affiliation":[{"name":"Clinical Pharmacology and Therapeutics Unit, Department of Medicine, University of Melbourne, Austin Health, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael A","family":"Krezel","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology and Therapeutics Unit, Department of Medicine, University of Melbourne, Austin Health, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda","family":"Rezmann","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology and Therapeutics Unit, Department of Medicine, University of Melbourne, Austin Health, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurie","family":"Chow","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology and Therapeutics Unit, Department of Medicine, University of Melbourne, Austin Health, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert George","family":"Frauman","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology and Therapeutics Unit, Department of Medicine, University of Melbourne, Austin Health, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William J","family":"Louis","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology and Therapeutics Unit, Department of Medicine, University of Melbourne, Austin Health, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon N","family":"Louis","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology and Therapeutics Unit, Department of Medicine, University of Melbourne, Austin Health, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2013,4,4]]},"reference":[{"key":"bibr1-1470320313483845","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-71-1-89"},{"key":"bibr2-1470320313483845","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199005313222203"},{"key":"bibr3-1470320313483845","doi-asserted-by":"publisher","DOI":"10.1124\/mol.55.1.142"},{"key":"bibr4-1470320313483845","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.65.092101.142243"},{"key":"bibr5-1470320313483845","first-page":"H806","volume":"258","author":"Aceto JF","year":"1990","journal-title":"Am J Physiol"},{"key":"bibr6-1470320313483845","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ph.54.030192.001303"},{"key":"bibr7-1470320313483845","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/5.5.276"},{"key":"bibr8-1470320313483845","doi-asserted-by":"publisher","DOI":"10.1007\/BF00227876"},{"key":"bibr9-1470320313483845","first-page":"H610","volume":"259","author":"Baker KM","year":"1990","journal-title":"Am J Physiol"},{"key":"bibr10-1470320313483845","doi-asserted-by":"publisher","DOI":"10.1172\/JCI24178"},{"key":"bibr11-1470320313483845","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-668X(02)00829-1"},{"key":"bibr12-1470320313483845","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.82.11.1145"},{"key":"bibr13-1470320313483845","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.81.4.1161"},{"key":"bibr14-1470320313483845","first-page":"H1370","volume":"275","author":"Ritchie RH","year":"1998","journal-title":"Am J Physiol"},{"key":"bibr15-1470320313483845","doi-asserted-by":"publisher","DOI":"10.1007\/s004240100710"},{"key":"bibr16-1470320313483845","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.59.1.551"},{"key":"bibr17-1470320313483845","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.73.3.413"},{"key":"bibr18-1470320313483845","doi-asserted-by":"crossref","first-page":"H29","DOI":"10.1152\/ajpcell.1996.271.4.C1250","volume":"271","author":"Wada H","year":"1996","journal-title":"Am J Physiol"},{"key":"bibr19-1470320313483845","first-page":"H844","volume":"267","author":"Lopez JJ","year":"1994","journal-title":"Am J Physiol"},{"key":"bibr20-1470320313483845","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.73.3.439"},{"key":"bibr21-1470320313483845","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.1.22"},{"key":"bibr22-1470320313483845","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.23.10663"},{"key":"bibr23-1470320313483845","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117710"},{"key":"bibr24-1470320313483845","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.96.11.3954"},{"key":"bibr25-1470320313483845","doi-asserted-by":"publisher","DOI":"10.1006\/jmcc.1997.0448"},{"key":"bibr26-1470320313483845","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2008.08.009"},{"key":"bibr27-1470320313483845","doi-asserted-by":"publisher","DOI":"10.1002\/0470032103.ch7"},{"key":"bibr28-1470320313483845","doi-asserted-by":"publisher","DOI":"10.1080\/08037050310001057"},{"key":"bibr29-1470320313483845","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-200308000-00001"},{"key":"bibr30-1470320313483845","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000100445.80029.8E"},{"key":"bibr31-1470320313483845","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000048340.53100.43"},{"key":"bibr32-1470320313483845","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00361.2003"},{"key":"bibr33-1470320313483845","doi-asserted-by":"publisher","DOI":"10.1172\/JCI10037"},{"key":"bibr34-1470320313483845","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.104.3.346"},{"key":"bibr35-1470320313483845","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000033826.52681.37"},{"key":"bibr36-1470320313483845","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M403880200"},{"key":"bibr37-1470320313483845","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000150662.51436.14"},{"key":"bibr38-1470320313483845","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2006.05.021"},{"key":"bibr39-1470320313483845","doi-asserted-by":"publisher","DOI":"10.1271\/bbb.100176"},{"key":"bibr40-1470320313483845","doi-asserted-by":"publisher","DOI":"10.1007\/s100380050003"},{"key":"bibr41-1470320313483845","doi-asserted-by":"publisher","DOI":"10.1096\/fj.02-0934fje"},{"key":"bibr42-1470320313483845","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(00)00299-6"},{"key":"bibr43-1470320313483845","doi-asserted-by":"publisher","DOI":"10.1210\/me.2006-0005"},{"key":"bibr44-1470320313483845","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0007239"},{"key":"bibr45-1470320313483845","doi-asserted-by":"publisher","DOI":"10.1002\/pros.20738"},{"key":"bibr46-1470320313483845","doi-asserted-by":"publisher","DOI":"10.1002\/pros.21192"},{"key":"bibr47-1470320313483845","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(76)90527-3"},{"key":"bibr48-1470320313483845","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(76)90447-X"},{"key":"bibr49-1470320313483845","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.10420"},{"key":"bibr50-1470320313483845","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/cdg637"},{"key":"bibr51-1470320313483845","doi-asserted-by":"publisher","DOI":"10.1210\/me.2003-0309"},{"key":"bibr52-1470320313483845","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-879X2002000900001"},{"key":"bibr53-1470320313483845","doi-asserted-by":"publisher","DOI":"10.1006\/jmcc.1999.0934"},{"key":"bibr54-1470320313483845","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.28.4.635"},{"key":"bibr55-1470320313483845","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.30.4.796"},{"key":"bibr56-1470320313483845","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000193504.51489.cf"},{"key":"bibr57-1470320313483845","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00174.2006"},{"key":"bibr58-1470320313483845","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.17.2.257"},{"key":"bibr59-1470320313483845","doi-asserted-by":"crossref","first-page":"S95","DOI":"10.1097\/00004872-199609002-00018","volume":"14","author":"Unger T","year":"1996","journal-title":"J Hypertens Suppl"},{"key":"bibr60-1470320313483845","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/15.suppl_D.98"},{"key":"bibr61-1470320313483845","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(89)92133-5"},{"key":"bibr62-1470320313483845","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(93)90665-5"},{"key":"bibr63-1470320313483845","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.33.2.613"},{"key":"bibr64-1470320313483845","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000093193.63314.D9"},{"key":"bibr65-1470320313483845","first-page":"F239","volume":"265","author":"Bagby SP","year":"1993","journal-title":"Am J Physiol"},{"key":"bibr66-1470320313483845","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.2009.05221.x"}],"container-title":["Journal of the Renin-Angiotensin-Aldosterone System"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1470320313483845","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1470320313483845","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1470320313483845","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:38:45Z","timestamp":1777509525000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1470320313483845"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4,4]]},"references-count":66,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["10.1177\/1470320313483845"],"URL":"https:\/\/doi.org\/10.1177\/1470320313483845","relation":{},"ISSN":["1470-3203","1752-8976"],"issn-type":[{"value":"1470-3203","type":"print"},{"value":"1752-8976","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,4]]}}}