{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T20:39:45Z","timestamp":1791319185693,"version":"4.3.1"},"reference-count":30,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2013,7,11]],"date-time":"2013-07-11T00:00:00Z","timestamp":1373500800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Renin Angiotensin Aldosterone Syst"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>The relationship between the angiotensin-converting enzyme ( ACE) insertion\/deletion (I\/D) polymorphism and psoriasis has previously been studied mainly in Caucasians and only once in Asians. The aim of this study is to evaluate the association between the ACE I\/D polymorphism and the risk of psoriasis in a Chinese population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods:<\/jats:title>\n                    <jats:p>The study population consisted of 668 psoriasis patients and 668 matched control subjects. The ACE I\/D gene polymorphism was analyzed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The frequency of the ACE II genotype (odds ratio (OR) = 1.32, 95% confidence interval (CI) = 1.06, 1.63; P = 0.01) and I allele (OR = 1.25, 95% CI = 1.06, 1.48; P = 0.01) in patients with psoriasis was significantly higher than that in the control group. And the D allele frequency in patients with psoriasis was significantly lower (OR = 0.80, 95% CI = 0.68, 0.95; P = 0.01) than that in the control group. When stratified by family history, the frequency of the DD genotype was marginally significantly lower in patients with a positive family history of psoriasis (familial psoriasis) than in those with negative (sporadic psoriasis) (OR = 0.47, 95% CI = 0.23, 0.97; P = 0.04). When stratified by onset of the disease, type of psoriasis and the severity of psoriasis, no statistically significant result was observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Our study suggested that the ACE II genotype and I allele might confer susceptibility to psoriasis in a Chinese population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1470320313494433","type":"journal-article","created":{"date-parts":[[2013,7,12]],"date-time":"2013-07-12T00:22:09Z","timestamp":1373588529000},"page":"39-43","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Angiotensin-converting enzyme insertion\/deletion polymorphism and susceptibility to psoriasis in a Chinese population"],"prefix":"10.1177","volume":"15","author":[{"given":"KeDa","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Pathology, College of Basic Medical Sciences, Central South University, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, XiangYa Hospital, Central South University, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"FangFang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology, XiangYa Hospital, Central South University, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Dermatology, XiangYa Hospital, Central South University, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SaiLan","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Pathology, XiangYa Second Hospital, Central South University, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pathology, XiangYa Third Hospital, Central South University, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DeYun","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Pathology, College of Basic Medical Sciences, Central South University, 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