{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T01:57:32Z","timestamp":1777859852065,"version":"3.51.4"},"reference-count":83,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2014,7,16]],"date-time":"2014-07-16T00:00:00Z","timestamp":1405468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Renin Angiotensin Aldosterone Syst"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The diagnosis of primary aldosteronism (PA) among the older-aged population has posed a crucial challenge. Among patients over 50 years old, this trial assessed comparability of the performance of two PA diagnostic tests: losartan and captopril suppression tests.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A post-hoc subgroup analysis from a prospective cohort was conducted by the TAIPAI (Taiwan Primary Aldosteronism Investigation) group between July 2003 and July 2006. Of the 160 patients in the cohort, 60 patients over 50 years old received captopril and losartan tests to confirm PA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Among the 60 patients over 50 years old, 31 patients had PA confirmed by standardized protocol. The area under the receiver-operating characteristic (ROC) curve for post-captopril aldosterone was significantly less than that for post-losartan plasma aldosterone concentration (PAC) (0.87 vs 0.94, p=0.02). Using the aldosterone-renin ratio (ARR)&gt;35 with PAC&gt;10 ng\/dl, the specificity was 82.76% vs 93.1% and the sensitivity was 77.42% vs 87.10% for the captopril and losartan tests, respectively. The equivalence between the two tests were confirmed by the exact McNemar\u2019s test ( p=1.0).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The losartan test showed comparable accuracy to confirm PA. Verification of this \u201celderly-friendly\u201d confirmatory test will be the first step to prepare a specific diagnostic model of PA for the older-aged population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1470320313498632","type":"journal-article","created":{"date-parts":[[2014,7,16]],"date-time":"2014-07-16T22:59:25Z","timestamp":1405551565000},"page":"587-598","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["The value of losartan suppression test in the confirmatory diagnosis of primary aldosteronism in patients over 50 years old"],"prefix":"10.1177","volume":"16","author":[{"given":"Chin-Chi","family":"Kuo","sequence":"first","affiliation":[{"name":"Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, USA"},{"name":"Division of Nephrology, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Poojitha","family":"Balakrishnan","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yenh-Chen","family":"Hsein","sequence":"additional","affiliation":[{"name":"Division of Clinical Pathology, National Taiwan University Hospital Yun-Lin Branch, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vin-Cent","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, National Taiwan University Hospital, and College of Medicine, National Taiwan University, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shih-Chieh Jeff","family":"Chueh","sequence":"additional","affiliation":[{"name":"Cleveland Clinic Lerner College of Medicine and Glickman Urological and Kidney Institute, Cleveland Clinic, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yung-Ming","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, National Taiwan University Hospital, and College of Medicine, National Taiwan University, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwan-Dun","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, National Taiwan University Hospital, and College of Medicine, National Taiwan University, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming-Jiuh","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Forensic Medicine, National Taiwan University Hospital, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"TAIPAI group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vin-Cent","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yen-Hung","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Luwn","family":"Ho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hung-Wei","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lian-Yu","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fu-Chang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kao-Lang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuo-Meng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuo-How","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yung-Ming","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chin-Chi","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chin-Chen","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shih-Chieh","family":"Chueh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ching-Chu","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shih-Cheng","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruoh-Fang","family":"Yen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-Chou","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bor-Sen","family":"Hsieh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwan-Dun","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,7,16]]},"reference":[{"key":"bibr1-1470320313498632","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)17741-1"},{"key":"bibr2-1470320313498632","doi-asserted-by":"publisher","DOI":"10.1001\/jama.294.4.466"},{"key":"bibr3-1470320313498632","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.18.2363"},{"key":"bibr4-1470320313498632","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-199405000-00015"},{"key":"bibr5-1470320313498632","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-7061(98)00011-9"},{"key":"bibr6-1470320313498632","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1016\/j.jacc.2011.01.008","volume":"57","author":"Aronow WS","year":"2011","journal-title":"J Am Coll Cardiol"},{"key":"bibr7-1470320313498632","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000079505.25750.11"},{"key":"bibr8-1470320313498632","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-1135"},{"key":"bibr9-1470320313498632","doi-asserted-by":"publisher","DOI":"10.1177\/1470320310391331"},{"key":"bibr10-1470320313498632","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-1733"},{"key":"bibr11-1470320313498632","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2010.02462.x"},{"key":"bibr12-1470320313498632","doi-asserted-by":"publisher","DOI":"10.1038\/ajh.2009.89"},{"key":"bibr13-1470320313498632","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-148-1-200801010-00189"},{"key":"bibr14-1470320313498632","doi-asserted-by":"publisher","DOI":"10.4168\/aair.2010.2.3.195"},{"key":"bibr15-1470320313498632","doi-asserted-by":"publisher","DOI":"10.1093\/ptj\/85.3.257"},{"key":"bibr16-1470320313498632","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.19.2560"},{"key":"bibr17-1470320313498632","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-6175.2004.03607.x"},{"key":"bibr18-1470320313498632","doi-asserted-by":"publisher","DOI":"10.1038\/jhh.2008.120"},{"key":"bibr19-1470320313498632","first-page":"598","volume":"100","author":"Wu KD","year":"2001","journal-title":"J Formos Med Assoc"},{"key":"bibr20-1470320313498632","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1992.56"},{"key":"bibr21-1470320313498632","volume-title":"Product Information","author":"Capoten Captopril","year":"1996"},{"key":"bibr22-1470320313498632","doi-asserted-by":"publisher","DOI":"10.1172\/JCI104239"},{"key":"bibr23-1470320313498632","doi-asserted-by":"publisher","DOI":"10.1007\/BF01466736"},{"key":"bibr24-1470320313498632","doi-asserted-by":"publisher","DOI":"10.1177\/1470320310391329"},{"key":"bibr25-1470320313498632","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.109.064873"},{"key":"bibr26-1470320313498632","first-page":"404","volume":"103","author":"Aiba M","year":"1981","journal-title":"Am J Pathol"},{"key":"bibr27-1470320313498632","doi-asserted-by":"publisher","DOI":"10.1053\/meta.2002.30498"},{"key":"bibr28-1470320313498632","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2005.09.027"},{"key":"bibr29-1470320313498632","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2009.06.014"},{"key":"bibr30-1470320313498632","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-2338"},{"key":"bibr31-1470320313498632","first-page":"2854","volume":"85","author":"Loh KC","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"bibr32-1470320313498632","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.107.091827"},{"key":"bibr33-1470320313498632","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcm101"},{"key":"bibr34-1470320313498632","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1993.00410180075008"},{"key":"bibr35-1470320313498632","doi-asserted-by":"publisher","DOI":"10.1037\/h0026256"},{"key":"bibr36-1470320313498632","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000133321.00456.00"},{"key":"bibr37-1470320313498632","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)66399-4"},{"key":"bibr38-1470320313498632","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1987.tb02323.x"},{"key":"bibr39-1470320313498632","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.295.6604.943"},{"key":"bibr40-1470320313498632","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-0104"},{"key":"bibr41-1470320313498632","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e31821daaf6"},{"key":"bibr42-1470320313498632","doi-asserted-by":"publisher","DOI":"10.1038\/ncpneph0151"},{"key":"bibr43-1470320313498632","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2011.76"},{"key":"bibr44-1470320313498632","unstructured":"United States Census Bureau. Age and Sex: The older population in the United States. http:\/\/www.census.gov\/population\/age\/data\/2011.html (accessed 20 Jun 2012)."},{"key":"bibr45-1470320313498632","first-page":"394","volume":"90","author":"Rayner BL","year":"2000","journal-title":"S Afr Med J"},{"key":"bibr46-1470320313498632","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jhh.1001948"},{"key":"bibr47-1470320313498632","doi-asserted-by":"publisher","DOI":"10.2337\/dc07-0031"},{"key":"bibr48-1470320313498632","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-7176.2009.00120.x"},{"key":"bibr49-1470320313498632","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e32833d0177"},{"key":"bibr50-1470320313498632","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(05)80002-2"},{"key":"bibr51-1470320313498632","first-page":"17","volume":"4","author":"Benchetrit S","year":"2002","journal-title":"Isr Med Assoc J"},{"key":"bibr52-1470320313498632","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.25.11"},{"key":"bibr53-1470320313498632","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.25.737"},{"key":"bibr54-1470320313498632","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjhyper.2005.05.013"},{"key":"bibr55-1470320313498632","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.30.1083"},{"key":"bibr56-1470320313498632","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2010.25.7.1041"},{"key":"bibr57-1470320313498632","doi-asserted-by":"publisher","DOI":"10.1177\/1479164109350556"},{"key":"bibr58-1470320313498632","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-2743"},{"key":"bibr59-1470320313498632","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-2803"},{"key":"bibr60-1470320313498632","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-0354"},{"key":"bibr61-1470320313498632","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-7061(02)02969-2"},{"key":"bibr62-1470320313498632","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1510073"},{"key":"bibr63-1470320313498632","doi-asserted-by":"publisher","DOI":"10.1080\/08037050510034329"},{"key":"bibr64-1470320313498632","doi-asserted-by":"publisher","DOI":"10.1177\/000313480507101015"},{"key":"bibr65-1470320313498632","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2004100878"},{"key":"bibr66-1470320313498632","doi-asserted-by":"publisher","DOI":"10.1001\/jama.295.22.2638"},{"key":"bibr67-1470320313498632","doi-asserted-by":"publisher","DOI":"10.1007\/BF03349173"},{"key":"bibr68-1470320313498632","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.30.111"},{"key":"bibr69-1470320313498632","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e3280108e6f"},{"key":"bibr70-1470320313498632","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e32831286fd"},{"key":"bibr71-1470320313498632","doi-asserted-by":"publisher","DOI":"10.1038\/ajh.2008.175"},{"key":"bibr72-1470320313498632","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.108.122002"},{"key":"bibr73-1470320313498632","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-1851"},{"key":"bibr74-1470320313498632","doi-asserted-by":"publisher","DOI":"10.1038\/jhh.2010.65"},{"key":"bibr75-1470320313498632","doi-asserted-by":"publisher","DOI":"10.1001\/jama.294.6.716"},{"key":"bibr76-1470320313498632","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.9.4.509"},{"key":"bibr77-1470320313498632","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2007.33"},{"key":"bibr78-1470320313498632","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e3283550f93"},{"key":"bibr79-1470320313498632","author":"Fallo F","year":"2011","journal-title":"Horm Metab Res"},{"key":"bibr80-1470320313498632","doi-asserted-by":"publisher","DOI":"10.1111\/j.0006-341X.2001.00158.x"},{"key":"bibr81-1470320313498632","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-121-11-199412010-00010"},{"key":"bibr82-1470320313498632","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197810262991705"},{"key":"bibr83-1470320313498632","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.1987.tb00371.x"}],"container-title":["Journal of the Renin-Angiotensin-Aldosterone System"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1470320313498632","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1470320313498632","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1470320313498632","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:38:54Z","timestamp":1777509534000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1470320313498632"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,16]]},"references-count":83,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["10.1177\/1470320313498632"],"URL":"https:\/\/doi.org\/10.1177\/1470320313498632","relation":{},"ISSN":["1470-3203","1752-8976"],"issn-type":[{"value":"1470-3203","type":"print"},{"value":"1752-8976","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,16]]}}}