{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T01:57:20Z","timestamp":1777859840153,"version":"3.51.4"},"reference-count":32,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2014,2,4]],"date-time":"2014-02-04T00:00:00Z","timestamp":1391472000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Renin Angiotensin Aldosterone Syst"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Excessive activation of the sympathetic nervous system (SNS) and the renin-angiotensin system (RAS) are crucial and interacted closely in the pathogenesis of chronic cardiovascular diseases. This study investigated the effects of renal denervation (RDN) on the RAS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods:<\/jats:title>\n                    <jats:p>Eight Chinese Kunming dogs underwent bilateral RDN utilizing saline-irrigated radiofrequency ablation catheter. Blood pressure (BP) measurements, blood sampling assays and renal angiography were performed at baseline, 30 min, one month and three months after ablation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>During three months of follow-up, RDN caused a significant and uniform reduction in plasma level of renin, angiotensin II, and endothelin-1(ET-1), with the reduction of \u20135.7\u00b16.8 ( p=0.049), \u201319.4\u00b119.3 ( p=0.025), and \u201322.4\u00b121 pg\/ml ( p=0.02) for plasma renin, \u201310.6\u00b17.2 ( p=0.004), \u201315.9\u00b18.8 ( p=0.001), and \u201315.2\u00b19.6 pg\/ml ( p=0.003) for plasma angiotensin II, as well as \u20133.9\u00b13 ( p=0.007), \u201310.8\u00b15 ( p&lt;0.001), and \u201314.6\u00b16.1 pg\/ml ( p&lt;0.001) for plasma ET-1. RDN utilizing a saline-irrigated catheter also caused a progressive and substantial BP reduction of \u201319\u00b122\/\u20138\u00b113, \u201330\u00b113\/\u201313\u00b114, and \u201336\u00b120\/\u201316\u00b114 mm Hg ( p=0.045, p&lt;0.001, and p&lt;0.002 for systolic BP; p=0.14, p=0.036, and p=0.014 for diastolic BP) without ablation-related complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>RDN substantially decreased BP and also significantly decreased the plasma levels of RAS and ET-1, which might be implicated in the mechanism of BP reduction by RDN.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1470320313506480","type":"journal-article","created":{"date-parts":[[2014,2,5]],"date-time":"2014-02-05T00:26:02Z","timestamp":1391559962000},"page":"532-539","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":20,"title":["Effects of renal sympathetic denervation using saline-irrigated radiofrequency ablation catheter on the activity of the renin-angiotensin system and endothelin-1"],"prefix":"10.1177","volume":"15","author":[{"given":"Jiayi","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiyu","family":"Ling","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weijie","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huaan","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanping","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinqi","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Long","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaojie","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peilin","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zengzhang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernhard","family":"Zrenner","sequence":"additional","affiliation":[{"name":"Medizinische Klinik I, Krankenhaus Landshut\/Achdorf, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuehui","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,2,4]]},"reference":[{"key":"bibr1-1470320313506480","doi-asserted-by":"publisher","DOI":"10.4061\/2011\/642416"},{"key":"bibr2-1470320313506480","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.73.4.615"},{"key":"bibr3-1470320313506480","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi184"},{"key":"bibr4-1470320313506480","doi-asserted-by":"publisher","DOI":"10.1111\/jch.12017"},{"key":"bibr5-1470320313506480","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000034043.16664.96"},{"key":"bibr6-1470320313506480","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00832.2009"},{"key":"bibr7-1470320313506480","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000047205.52509.8A"},{"key":"bibr8-1470320313506480","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60825-3"},{"key":"bibr9-1470320313506480","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.109.138610"},{"key":"bibr10-1470320313506480","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60566-3"},{"key":"bibr11-1470320313506480","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)62039-9"},{"key":"bibr12-1470320313506480","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.110.163014"},{"key":"bibr13-1470320313506480","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.130880"},{"key":"bibr14-1470320313506480","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc0904179"},{"key":"bibr15-1470320313506480","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.111.00194"},{"key":"bibr16-1470320313506480","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-199816121-00007"},{"key":"bibr17-1470320313506480","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.26.1.83"},{"key":"bibr18-1470320313506480","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.28.5.806"},{"key":"bibr19-1470320313506480","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.30.1.29"},{"key":"bibr20-1470320313506480","first-page":"1192","volume":"37","author":"Barajas L","year":"1978","journal-title":"Federation Proc"},{"key":"bibr21-1470320313506480","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00258.2005"},{"key":"bibr22-1470320313506480","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-011-0335-y"},{"key":"bibr23-1470320313506480","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-7061(99)00005-9"},{"key":"bibr24-1470320313506480","first-page":"F738","volume":"266","author":"Holmer S","year":"1994","journal-title":"Am J Physiol"},{"key":"bibr25-1470320313506480","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-198835050-00001"},{"key":"bibr26-1470320313506480","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.25.4.893"},{"key":"bibr27-1470320313506480","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(87)90061-0"},{"key":"bibr28-1470320313506480","doi-asserted-by":"publisher","DOI":"10.1002\/ca.21280"},{"key":"bibr29-1470320313506480","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.87.6.1816"},{"key":"bibr30-1470320313506480","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2012.01.027"},{"key":"bibr31-1470320313506480","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e32835821e5"},{"key":"bibr32-1470320313506480","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.89.1.493"}],"container-title":["Journal of the Renin-Angiotensin-Aldosterone System"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1470320313506480","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1470320313506480","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1470320313506480","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:38:42Z","timestamp":1777509522000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1470320313506480"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,4]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["10.1177\/1470320313506480"],"URL":"https:\/\/doi.org\/10.1177\/1470320313506480","relation":{},"ISSN":["1470-3203","1752-8976"],"issn-type":[{"value":"1470-3203","type":"print"},{"value":"1752-8976","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,4]]}}}