{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T01:57:22Z","timestamp":1777859842411,"version":"3.51.4"},"reference-count":19,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2014,4,17]],"date-time":"2014-04-17T00:00:00Z","timestamp":1397692800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Renin Angiotensin Aldosterone Syst"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>This is a report of a clinical trial on the therapeutic efficacy and safety of combined aliskiren and losartan (an angiotensin II receptor blocker (ARB)) versus aliskiren alone and ARB alone in non-diabetic chronic kidney disease (CKD) over a 3-year period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods:<\/jats:title>\n                    <jats:p>This was a randomised trial in 155 patients with non-diabetic CKD comparing aliskiren (150 mg\/day) ( n=52) versus losartan (100 mg\/day) ( n=52) and the third group aliskiren (150 mg\/day) combined with losartan (100 mg\/day) ( n=51). The trial utilised primary renal end points of eGFR &lt;15 ml\/min or end-stage renal failure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>All three groups had significant reduction of proteinuria ( p&lt;0.001 for all). The changes in eGFR, total urinary protein from baseline to each year were not significantly different between the three therapeutic groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This study in non-diabetic CKD patients showed that combination therapy with aliskiren and ARB was as efficacious as aliskiren alone and ARB alone. There was one patient who developed a non-fatal stroke in the combined aliskiren and ARB group while the other two groups had none.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1470320313510584","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T02:15:56Z","timestamp":1397787356000},"page":"515-522","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Aliskiren and losartan trial in non-diabetic chronic kidney disease"],"prefix":"10.1177","volume":"15","author":[{"given":"Keng-Thye","family":"Woo","sequence":"first","affiliation":[{"name":"Department of Renal Medicine, Singapore General Hospital, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui-Lin","family":"Choong","sequence":"additional","affiliation":[{"name":"Department of Renal Medicine, Singapore General Hospital, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kok-Seng","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Renal Medicine, Singapore General Hospital, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han-Kim","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Renal Medicine, Singapore General Hospital, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marjorie","family":"Foo","sequence":"additional","affiliation":[{"name":"Department of Renal Medicine, Singapore General Hospital, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Fook-Chong","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, Singapore General Hospital, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evan JC","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Nephrology, National University of Singapore, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vathsala","family":"Anantharaman","sequence":"additional","affiliation":[{"name":"Department of Nephrology, National University of Singapore, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grace SL","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Renal Medicine, Singapore General Hospital, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Choong-Meng","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Renal Medicine, Singapore General Hospital, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,4,17]]},"reference":[{"key":"bibr1-1470320313510584","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000100125.21491.46"},{"key":"bibr2-1470320313510584","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2007090970"},{"key":"bibr3-1470320313510584","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2009.105"},{"key":"bibr4-1470320313510584","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-5521(00)00134-4"},{"key":"bibr5-1470320313510584","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0708379"},{"key":"bibr6-1470320313510584","first-page":"3","volume":"14","author":"Health Sciences Authority","year":"2012","journal-title":"Early termination of aliskiren study due to adverse effects"},{"key":"bibr7-1470320313510584","unstructured":"Health Sciences Authority. 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