{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T01:57:34Z","timestamp":1777859854021,"version":"3.51.4"},"reference-count":26,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2014,1,24]],"date-time":"2014-01-24T00:00:00Z","timestamp":1390521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Renin Angiotensin Aldosterone Syst"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>In this study, we investigated whether AngII receptors (AT1a and AT2) contributed to the development of the aldosterone-induced inflammatory response of rat mesangial cells (RMCs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods:<\/jats:title>\n                    <jats:p>RMCs were isolated from the glomeruli of normal or diabetic rats which were produced by injection of streptozotocin, and cultured in high-glucose media. In order to evaluate the effects of aldosterone, the expression of AT1a, AT2, NF-\u03baB and MCP-1 was detected. In addition, in order to evaluate the role of Ang II receptors, AT1a and AT2 genes were blocked and the expression of NF-\u03baB and MCP-1 was detected. Moreover, for assessing the relationship between NF-\u03baB and MCP-1, the NF-\u03baB gene was blocked and MCP-1 expression was detected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Aldosterone significantly increased AT1a, AT2, NF-\u03baB and MCP-1 levels in RMCs in a dose-dependent manner, whereas eplerenone (EPI), a selective aldosterone antagonist, partly inhibited the effects of aldosterone. When AT1a and AT2 genes were blocked, the expression of NF-\u03baB and MCP-1 was greatly inhibited. Moreover, when the NF-\u03baB gene was silenced, the expression of MCP-1 was reduced.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>We demonstrated that aldosterone induced an inflammatory response in RMCs cultured in high-glucose media via the AT1a and AT2 pathways.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1470320313519486","type":"journal-article","created":{"date-parts":[[2014,1,25]],"date-time":"2014-01-25T00:13:43Z","timestamp":1390608823000},"page":"739-748","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Aldosterone-induced inflammatory response of mesangial cells via angiotension II receptors"],"prefix":"10.1177","volume":"16","author":[{"given":"Jianbing","family":"Hao","sequence":"first","affiliation":[{"name":"Department of Nephropathy and Hemodialysis, The First Affiliated Hospital of Harbin Medical University, Harbin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liansheng","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Nephropathy and Hemodialysis, The First Affiliated Hospital of Harbin Medical University, Harbin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Nephropathy and Hemodialysis, The First Affiliated Hospital of Harbin Medical University, Harbin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deyang","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Nephropathy and Hemodialysis, The First Affiliated Hospital of Harbin Medical University, Harbin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lirong","family":"Hao","sequence":"additional","affiliation":[{"name":"Department of Nephropathy and Hemodialysis, The First Affiliated Hospital of Harbin Medical University, Harbin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,1,24]]},"reference":[{"key":"bibr1-1470320313519486","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2008050549"},{"key":"bibr2-1470320313519486","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00484.2007"},{"key":"bibr3-1470320313519486","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1797.2005.00455.x"},{"key":"bibr4-1470320313519486","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000259797.48382.b2"},{"key":"bibr5-1470320313519486","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000193504.51489.cf"},{"key":"bibr6-1470320313519486","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000130564.75008.F5"},{"key":"bibr7-1470320313519486","doi-asserted-by":"publisher","DOI":"10.1177\/1470320310369603"},{"key":"bibr8-1470320313519486","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2009.234"},{"key":"bibr9-1470320313519486","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e3282f3e9e6"},{"key":"bibr10-1470320313519486","doi-asserted-by":"publisher","DOI":"10.1177\/1470320309347787"},{"key":"bibr11-1470320313519486","doi-asserted-by":"publisher","DOI":"10.1159\/000191467"},{"key":"bibr12-1470320313519486","doi-asserted-by":"publisher","DOI":"10.1097\/MNH.0b013e3282f29028"},{"key":"bibr13-1470320313519486","doi-asserted-by":"publisher","DOI":"10.1097\/00041552-200501000-00011"},{"key":"bibr14-1470320313519486","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2007.07.008"},{"key":"bibr15-1470320313519486","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfg109"},{"key":"bibr16-1470320313519486","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2005111196"},{"key":"bibr17-1470320313519486","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2004110961"},{"key":"bibr18-1470320313519486","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0704131"},{"key":"bibr19-1470320313519486","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1681\/ASN.2007040484","volume":"19","author":"Juan 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