{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T02:40:27Z","timestamp":1784774427779,"version":"3.55.0"},"reference-count":20,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2014,8,20]],"date-time":"2014-08-20T00:00:00Z","timestamp":1408492800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Renin Angiotensin Aldosterone Syst"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:p>\n                    Primary aldosteronism (PA) is estimated to occur in 5\u201312% of patients with hypertension. Assessment of aldosterone \/ plasma renin activity (PRA) ratio (ARR) has been used as a screening test in patients suspected of PA. Direct determination of renin (DRC) and calculation of aldosterone \/ direct renin concentration ratio (ADRR) could be similarly useful for screening patients suspected of PA. The study included 62 patients with indication for evaluation of the renin-angiotensin-aldosterone system and 35 healthy volunteers. In all participants we measured concentrations of serum aldosterone, plasma direct renin, and PRA after a night\u2019s rest and again after walking for two hours. The concentrations of aldosterone, direct renin, and PRA were measured by isotopic methods (radioimmunoassay (RIA) \/ immunoradiometric assay (IRMA)). Correlations of ARR with ADRR in the supine position were r = 0.9162, r\n                    <jats:sup>2<\/jats:sup>\n                    = 0.8165 ( p &lt; 0.01); and in the up-right position were r = 0.7765, r\n                    <jats:sup>2<\/jats:sup>\n                    = 0.9153 ( p &lt; 0.01). The cut-off values of ARR and ADRR \u2265 100 presented highest specificity (99%) for the diagnosis of PA; however, quite acceptable specificity and sensitivity (&gt; 80% and 100%, respectively) appeared for the ratios \u2265 30. We suggest that for practical and economic reasons ARR can be replaced by ADRR.\n                  <\/jats:p>","DOI":"10.1177\/1470320313519487","type":"journal-article","created":{"date-parts":[[2014,8,20]],"date-time":"2014-08-20T22:52:06Z","timestamp":1408575126000},"page":"1298-1305","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":25,"title":["The ratios of aldosterone \/ plasma renin activity (ARR) versus aldosterone \/ direct renin concentration (ADRR)"],"prefix":"10.1177","volume":"16","author":[{"given":"Piotr","family":"Glinicki","sequence":"first","affiliation":[{"name":"Department of Endocrinology, The Centre of Postgraduate Medical Education, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wojciech","family":"Jeske","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, The Centre of Postgraduate Medical Education, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucyna","family":"Bednarek-Papierska","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, The Centre of Postgraduate Medical Education, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Kruszy\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, The Centre of Postgraduate Medical Education, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u0142gorzata","family":"Gietka-Czernel","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, The Centre of Postgraduate Medical Education, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"El\u017cbieta","family":"Ros\u0142onowska","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, The Centre of Postgraduate Medical Education, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jadwiga","family":"S\u0142owi\u0144ska-Srzednicka","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, The Centre of Postgraduate Medical Education, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Kasperlik-Za\u0142uska","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, The Centre of Postgraduate Medical Education, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wojciech","family":"Zgliczy\u0144ski","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, The Centre of Postgraduate Medical Education, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2014,8,20]]},"reference":[{"key":"bibr1-1470320313519487","first-page":"2","volume":"61","author":"My\u015bliwiec J","year":"2010","journal-title":"Endokrynol 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