{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T01:57:34Z","timestamp":1777859854921,"version":"3.51.4"},"reference-count":23,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2014,8,20]],"date-time":"2014-08-20T00:00:00Z","timestamp":1408492800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Renin Angiotensin Aldosterone Syst"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>We analyzed the efficacy and safety of combination therapy of high-dose losartan (100 mg\/day) and hydrochlorothiazide (HCTZ, 12.5 mg\/day) compared with those of the combination of high-dose telmisartan (80 mg\/day) and HCTZ (12.5 mg\/day).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Forty hypertensive patients who received a combination of high-dose telmisartan and HCTZ were enrolled. We applied a changeover strategy with switching from a combination of high-dose telmisartan and HCTZ to high-dose losartan and HCTZ. We divided the patients into two groups; those who achieved the target blood pressure (controlled group) and those who did not reach the target blood pressure (uncontrolled group) before the changeover and performed further analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The uncontrolled group showed a significant decrease in systolic blood pressure (SBP) (143\u00b112 mmHg to 126\u00b111 mmHg at three months). In addition, serum uric acid significantly decreased in all subjects, and in each of the controlled and uncontrolled groups. There were no significant changes in other biochemical parameters, such as potassium and hemoglobin A1c, at three months after the changeover in all subjects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Combination therapy with high-dose losartan and HCTZ was superior to the combination of telmisartan and HCTZ with respect to significant decreases in systolic blood pressure and serum uric acid in hypertensive patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1470320314529358","type":"journal-article","created":{"date-parts":[[2014,8,20]],"date-time":"2014-08-20T22:52:06Z","timestamp":1408575126000},"page":"1078-1084","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Efficacy and safety of combination therapy of high-dose losartan and hydrochlorothiazide in patients with hypertension"],"prefix":"10.1177","volume":"16","author":[{"given":"Yuhei","family":"Shiga","sequence":"first","affiliation":[{"name":"Department of Cardiology, Fukuoka University School of Medicine, Japan"},{"name":"Inoue Hospital, Fukuoka, Japan"},{"name":"Shirotani Hospital, Fukuoka, Japan"},{"name":"Fujisawa Clinic, Fukuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin-ichiro","family":"Miura","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Fukuoka University School of Medicine, Japan"},{"name":"Department of Molecular Cardiovascular Therapeutics, Fukuoka University School of Medicine, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Norimatsu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Fukuoka University School of Medicine, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuka","family":"Hitaka","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Fukuoka University School of Medicine, Japan"},{"name":"Inoue Hospital, Fukuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Itsuki","family":"Nagata","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Fukuoka University School of Medicine, Japan"},{"name":"Matsunaga Hospital, Fukuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rie","family":"Koyoshi","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Fukuoka University School of Medicine, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joji","family":"Morii","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Fukuoka University School of Medicine, Japan"},{"name":"Matsunaga Hospital, Fukuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Kuwano","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Fukuoka University School of Medicine, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshinari","family":"Uehara","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Fukuoka University School of Medicine, Japan"},{"name":"Department of Molecular Cardiovascular Therapeutics, Fukuoka University School of Medicine, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asao","family":"Inoue","sequence":"additional","affiliation":[{"name":"Inoue Hospital, Fukuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuro","family":"Shirotani","sequence":"additional","affiliation":[{"name":"Shirotani Hospital, Fukuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuaki","family":"Fujisawa","sequence":"additional","affiliation":[{"name":"Fujisawa Clinic, Fukuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eiyu","family":"Matsunaga","sequence":"additional","affiliation":[{"name":"Matsunaga Hospital, Fukuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keijiro","family":"Saku","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Fukuoka University School of Medicine, Japan"},{"name":"Department of Molecular Cardiovascular Therapeutics, Fukuoka University School of Medicine, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,8,20]]},"reference":[{"key":"bibr1-1470320314529358","doi-asserted-by":"publisher","DOI":"10.1038\/hr.2009.34"},{"key":"bibr2-1470320314529358","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e3281fc975a"},{"key":"bibr3-1470320314529358","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/S0140-6736(05)67185-1","volume":"366","author":"Dahl\u00f6f 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