{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T01:57:35Z","timestamp":1777859855241,"version":"3.51.4"},"reference-count":24,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2014,8,28]],"date-time":"2014-08-28T00:00:00Z","timestamp":1409184000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Renin Angiotensin Aldosterone Syst"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:sec>\n                    <jats:title>Hypothesis:<\/jats:title>\n                    <jats:p>Polymorphisms in angiotensin II type-1\/2 receptor genes ( AGTR1\/ AGTR2) may be involved in the pathogenesis of primary aldosteronism. The present study aims to reveal some loci susceptible to the disease on the genes in a group of Chinese Han nationality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods:<\/jats:title>\n                    <jats:p>A case-control study was conducted in 202 patients and 188 controls. Ten tagging SNPs on AGTR1\/ AGTR2 were genotyped for all subjects via the method of multiplex PCR-ligase detection reaction. Statistical analysis was performed with chi-square test and logistic regression analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>rs3772616 on the AGTR1 gene was a factor for susceptibility to primary aldosteronism ( p&lt;0.001), and the TT genotype significantly decreased the risk of primary aldosteronism compared with the CC homozygote ( p=0.008, adjusted OR=0.13; 95%CI: 0.03\u20130.59). The rs3772616 polymorphism was associated with primary aldosteronism under the additive and dominant models. The female carriers of the G allele in rs5193 showed a significant difference compared with the T allele.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The AGTR1 rs3772616 polymorphism can be considered as a hereditary marker for primary aldosteronism, and in the Chinese Han population the rs5193 G allele seems to predispose to it only in women.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1470320314534511","type":"journal-article","created":{"date-parts":[[2014,8,29]],"date-time":"2014-08-29T20:10:00Z","timestamp":1409343000000},"page":"880-887","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Association of polymorphisms in AGTR1 and AGTR2 genes with primary aldosteronism in the Chinese Han population"],"prefix":"10.1177","volume":"16","author":[{"given":"Zhun","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Urology, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Urology, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tingting","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Urology, Chengdu Military General Hospital, Chengdu, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinglai","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Urology, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaiyan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Urology, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Urology, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaxin","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Urology, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Urology, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baojun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Urology, Chinese PLA General Hospital, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Urology, Chinese PLA General Hospital, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinchun","family":"Xing","sequence":"additional","affiliation":[{"name":"Department of Urology, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,8,28]]},"reference":[{"key":"bibr1-1470320314534511","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2011.02531.x"},{"key":"bibr2-1470320314534511","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e328360ddf6"},{"key":"bibr3-1470320314534511","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-031337"},{"key":"bibr4-1470320314534511","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2009.09.027"},{"key":"bibr5-1470320314534511","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2001.01253.x"},{"key":"bibr6-1470320314534511","doi-asserted-by":"publisher","DOI":"10.1007\/s11596-011-0371-x"},{"key":"bibr7-1470320314534511","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cr.7290272"},{"key":"bibr8-1470320314534511","doi-asserted-by":"crossref","unstructured":"Li Z, Zhang Z, He Z, A partition-ligation-combination-subdivision EM algorithm for haplotype inference with multiallelic markers: Update of the SHEsis (http:\/\/analysis.bio-x.cn). 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