{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T01:57:18Z","timestamp":1777859838232,"version":"3.51.4"},"reference-count":37,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2014,9,1]],"date-time":"2014-09-01T00:00:00Z","timestamp":1409529600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"},{"start":{"date-parts":[[2014,9,1]],"date-time":"2014-09-01T00:00:00Z","timestamp":1409529600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Renin Angiotensin Aldosterone Syst"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Aldosterone antagonists may mediate their effects on heart failure through parathyroid hormone (PTH) in chronic kidney disease (CKD) patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Patients with CKD on spironolactone were selected and matched for age, gender, race, use of a vitamin D analogue, the number of antihypertensive medications, and CKD stage. PTH levels before and after the first prescription of spironolactone were measured. A thorough chart review was conducted to assess for heart failure hospitalizations. An adjusted Cox proportional model was used to calculate the hazard ratio (HR) for heart failure hospitalizations among cases versus controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      There were a total of 950 (mean age 67\u00b113 years, 40% men) patients with CKD. Of these, there were 48 hospitalizations for heart failure among the cases and 82 among the controls (HR 0.37; 95% confidence interval (CI) 0.19\u20130.74,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      =0.005). We noted a more significant decrease in PTH levels among the cases when compared to the controls (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt;0.0001). The adjusted hazard for heart failure hospitalization increased with higher PTH levels (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      =0.002) and mediation analysis revealed change in PTH level as a significant mediator of heart failure hospitalization (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      =0.04).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Aldosterone antagonists may be helpful in preventing hospitalizations for heart failure exacerbation in CKD patients through a PTH-mediated effect.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1470320314539180","type":"journal-article","created":{"date-parts":[[2014,7,7]],"date-time":"2014-07-07T23:39:35Z","timestamp":1404776375000},"page":"278-285","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Interplay of parathyroid hormone and aldosterone antagonist in prevention of heart failure hospitalizations in chronic kidney disease"],"prefix":"10.1177","volume":"15","author":[{"given":"Mona","family":"Hassan","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Henry Ford Hospital\/Wayne State University, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Waqas","family":"Qureshi","sequence":"additional","affiliation":[{"name":"Section of Cardiology, Wake Forest School of Medicine, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laila S","family":"Sroujieh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Henry Ford Hospital\/Wayne State University, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Derar","family":"Albashaireh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Henry Ford Hospital\/Wayne State University, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"BouMalham","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Henry Ford Hospital\/Wayne State University, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meghan","family":"Liroff","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Henry Ford Hospital\/Wayne State University, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Waseem","family":"Amjad","sequence":"additional","affiliation":[{"name":"Allama Iqbal Medical College, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatima","family":"Khalid","sequence":"additional","affiliation":[{"name":"Section of Nephrology and Hypertension, Wake Forest School of Medicine, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiba","family":"Hadid","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Henry Ford Hospital\/Wayne State University, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zaid","family":"Alirhayim","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Diseases, University of Kansas Medical Center, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,9]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2012.01.099"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e31820a55f5"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejheart.2003.09.010"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.3109\/0886022X.2013.819766"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.2174\/1871530311313010012"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2012-302779"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2011.08.039"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03347080"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2008.147652"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.113.01910"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.310.6976.358"},{"key":"e_1_3_2_13_2","first-page":"453","article-title":"Consequences of the implementation of K\/DOQI clinical practice guidelines for bone metabolism and disease in chronic kidney disease in a population of patients on chronic hemodialysis","volume":"20","author":"Arenas MD","year":"2007","unstructured":"Arenas MD, Alvarez-Ude F, Torregrosa V, et al. 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