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Two-kidney, one clip hypertensive rats were treated with quinapril (3.0 mg\/kg for 10 days), and then received propofol infusion (15 mg\/kg\/h) during ongoing arterial thrombosis. The hemodynamic and hemostatic parameters were assayed. Quinapril exerted a hypotensive effect increasing after propofol infusion. Quinapril showed an antithrombotic effect with the platelet adhesion reduction, fibrinolysis enhancement and oxidative stress reduction. Propofol did not influence thrombosis; however, it inhibited fibrinolysis and showed prooxidative action. The effect of propofol on fibrinolysis and oxidative stress was significantly lower in quinapril-pretreated rats. Mortality was increased among rats treated with both drugs together. Our study demonstrates that pretreatment with quinapril reduced the adverse effects of propofol on hemostasis. Unfortunately, co-administration of both drugs potentiated hypotension in rats, which corresponds to higher mortality.<\/jats:p>","DOI":"10.1177\/1470320316647239","type":"journal-article","created":{"date-parts":[[2016,5,11]],"date-time":"2016-05-11T21:23:53Z","timestamp":1463001833000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Quinapril decreases antifibrinolytic and prooxidative potential of propofol in arterial thrombosis in hypertensive rats"],"prefix":"10.1177","volume":"17","author":[{"given":"Marzena","family":"Wojewodzka-Zelezniakowicz","sequence":"first","affiliation":[{"name":"Department of Emergency and Disaster Medicine, Medical University of Bialystok, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wioleta","family":"Kisiel","sequence":"additional","affiliation":[{"name":"Department of Biopharmacy, Medical University of Bialystok, 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