{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T01:57:54Z","timestamp":1777859874285,"version":"3.51.4"},"reference-count":34,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Renin Angiotensin Aldosterone Syst"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Systemic sclerosis (SSc) shows variable clinical expression in different ethnic groups; vascular abnormalities are a prominent feature of this disease and its clinical expression may be influenced by genetic factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods:<\/jats:title>\n                    <jats:p>Herein, we describe 15 polymorphisms of the renin-angiotensin-aldosterone pathway in 170 Mexican admixed SSc patients (defined as patients with Mexican ancestry for at least 3 generations) and 199 healthy controls. We determined the presence of angiotensin II Type 1 receptor (AGTR1), angiotensin converting enzyme (ACE) and Endothelin 1 single nucleotide polymorphisms (SNPs) using 5\u2019 exonuclease TaqMan genotyping assays on a 7900HT real-time fast polymerase chain reaction (PCR) system.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>These polymorphisms had a similar distribution between SSc patients and controls, but we found that the AGTR1 G-680T (rs275652) ( p = 0.02; OR 3.5; 95%CI 1.2\u201310.4) and AGTR1 A-119G (rs275653) ( p = 0.008; OR 4.2; 95% CI 1.5\u201312.1) polymorphisms were associated with severe vascular involvement in our SSc patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>This is the first report of the association of these polymorphisms with vasculopathy in Mexican admixed SSc patients. Our findings suggested that the angiotensin II Type 1 receptor genotype may influence the clinical expression of vasculopathy in these patients. Functional analyses should follow.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1470320316659954","type":"journal-article","created":{"date-parts":[[2016,8,3]],"date-time":"2016-08-03T20:47:55Z","timestamp":1470257275000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Angiotensin II Type 1 receptor (AGTR1) gene polymorphisms are associated with vascular manifestations in patients with systemic sclerosis (SSc)"],"prefix":"10.1177","volume":"17","author":[{"given":"Tatiana S","family":"Rodr\u00edguez-Reyna","sequence":"first","affiliation":[{"name":"Department of Immunology and Rheumatology, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n [National Institute of Medical Sciences and Nutrition Salvador Zubir\u00e1n], Mexico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"N\u00fa\u00f1ez-Alvarez","sequence":"additional","affiliation":[{"name":"Department of Immunology and Rheumatology, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n [National Institute of Medical Sciences and Nutrition Salvador Zubir\u00e1n], Mexico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfredo","family":"Cruz-Lagunas","sequence":"additional","affiliation":[{"name":"Department of Immunology, Instituto Nacional de Enfermedades Respiratorias Ismael Cos\u00edo Villegas [National Institute of Respiratory Diseases Ismael Cos\u00edo Villegas], Mexico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosalinda","family":"Posadas-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Instituto Nacional de Cardiolog\u00eda Ignacio Ch\u00e1vez [Ignacio Ch\u00e1vez National Institute of Cardiology], Mexico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nonanzit","family":"P\u00e9rez-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Instituto Nacional de Cardiolog\u00eda Ignacio Ch\u00e1vez [Ignacio Ch\u00e1vez National Institute of Cardiology], Mexico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"Jim\u00e9nez-Alvarez","sequence":"additional","affiliation":[{"name":"Department of Immunology, Instituto Nacional de Enfermedades Respiratorias Ismael Cos\u00edo Villegas [National Institute of Respiratory Diseases Ismael Cos\u00edo Villegas], Mexico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo","family":"Ram\u00edrez-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Department of Immunology, Instituto Nacional de Enfermedades Respiratorias Ismael Cos\u00edo Villegas [National Institute of Respiratory Diseases Ismael Cos\u00edo Villegas], Mexico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julio","family":"Granados","sequence":"additional","affiliation":[{"name":"Department of Transplantation, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n [National Institute of Medical Sciences and Nutrition Salvador Zubir\u00e1n], Mexico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilberto","family":"Vargas-Alarc\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Instituto Nacional de Cardiolog\u00eda Ignacio Ch\u00e1vez [Ignacio Ch\u00e1vez National Institute of Cardiology], Mexico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joaqu\u00edn","family":"Z\u00fa\u00f1iga","sequence":"additional","affiliation":[{"name":"Department of Immunology, Instituto Nacional de Enfermedades Respiratorias Ismael 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