{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T01:57:58Z","timestamp":1777859878656,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Renin Angiotensin Aldosterone Syst"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Unstable angina is associated with an acute systemic inflammatory reaction and circulating T lymphocytes are activated. We investigated whether in unstable angina with marked immune system activation a selective upregulation of the circulating T-cell renin\u2013angiotensin system, modulated by angiotensin II, could occur.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We studied 13 unstable angina patients, 10 patients with stable angina and 10 healthy subjects. After T-lymphocyte isolation, mRNAs for angiotensin-converting enzyme (ACE) and angiotensin type 1 receptor (AT1-R) were quantified at baseline and after angiotensin II stimulation. ACE activity in cell pellet and supernatant and angiotensin II cell content were measured.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Plasma renin activity was similar in controls, stable and unstable angina patients. At baseline ACE and AT1-R mRNA levels were higher ( P&lt;0.05) in T cells from unstable angina patients than in T cells from stable angina patients and controls, and further increased after angiotensin II addition to cultured T cells. ACE activity of unstable angina T cells was significantly higher than that of T cells from controls and stable angina patients. Only in T cells from unstable angina patients did angiotensin II stimulation cause the almost complete release of ACE activity in the supernatant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The circulating T-cell-based renin\u2013angiotensin system from unstable angina patients was selectively upregulated. In vivo unstable angina T cells could locally increase angiotensin II concentration in tissues where they migrate independently of the circulating renin\u2013angiotensin system.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1470320317698849","type":"journal-article","created":{"date-parts":[[2017,3,10]],"date-time":"2017-03-10T05:55:33Z","timestamp":1489125333000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Persistent and selective upregulation of renin\u2013angiotensin system in circulating T lymphocytes in unstable angina"],"prefix":"10.1177","volume":"18","author":[{"given":"Mirella","family":"Coppo","sequence":"first","affiliation":[{"name":"Department of Experimental and Clinical Medicine, University of Florence, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuela","family":"Bandinelli","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine, University of Florence, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Chiostri","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine, University of Florence, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Loredana","family":"Poggesi","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine, University of Florence, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Boddi","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine, University of Florence, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,3,10]]},"reference":[{"key":"bibr1-1470320317698849","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000130944.49657.b8"},{"key":"bibr2-1470320317698849","doi-asserted-by":"publisher","DOI":"10.1042\/bj2900033"},{"key":"bibr3-1470320317698849","doi-asserted-by":"publisher","DOI":"10.1016\/0925-4439(94)90052-3"},{"key":"bibr4-1470320317698849","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.21.4.470"},{"key":"bibr5-1470320317698849","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.91.4.1129"},{"key":"bibr6-1470320317698849","doi-asserted-by":"publisher","DOI":"10.1016\/j.regpep.2008.07.010"},{"key":"bibr7-1470320317698849","doi-asserted-by":"publisher","DOI":"10.1001\/jama.290.22.2945"},{"key":"bibr8-1470320317698849","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000147415.40692.7f"},{"key":"bibr9-1470320317698849","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006070707"},{"key":"bibr10-1470320317698849","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2014.07.044"},{"key":"bibr11-1470320317698849","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000079025.38826.E1"},{"key":"bibr12-1470320317698849","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000245830.29764.84"},{"key":"bibr13-1470320317698849","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.09.009"},{"key":"bibr14-1470320317698849","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.97.22.2202"},{"key":"bibr15-1470320317698849","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200001203420301"},{"key":"bibr16-1470320317698849","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(02)02242-7"},{"key":"bibr17-1470320317698849","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.19.7.1623"},{"key":"bibr18-1470320317698849","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.900842"},{"key":"bibr19-1470320317698849","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.90521.2008"},{"key":"bibr20-1470320317698849","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006070707"},{"key":"bibr21-1470320317698849","doi-asserted-by":"publisher","DOI":"10.1038\/ajh.2011.32"},{"key":"bibr22-1470320317698849","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01368-7"},{"key":"bibr23-1470320317698849","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-09-0706"},{"key":"bibr24-1470320317698849","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20070657"},{"key":"bibr25-1470320317698849","doi-asserted-by":"publisher","DOI":"10.2119\/molmed.2014.00195"},{"key":"bibr26-1470320317698849","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.03.040"},{"key":"bibr27-1470320317698849","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcmed.2009.04.002"},{"key":"bibr28-1470320317698849","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000140269.55873.7b"},{"key":"bibr29-1470320317698849","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1135726100"},{"key":"bibr30-1470320317698849","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.112.300871"}],"container-title":["Journal 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