{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T02:57:47Z","timestamp":1778122667272,"version":"3.51.4"},"reference-count":27,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Renin Angiotensin Aldosterone Syst"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>This study evaluated the potential effect of hydration intensity on the role of angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs) on contrast-induced nephropathy in patients with renal insufficiency.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>All eligible patients were included and stratified according to hydration intensity defined as saline hydration volume to body weight tertiles: &lt;10.21 mL\/kg, 10.21 to &lt;17.86 mL\/kg, and \u2a7e17.86 mL\/kg.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>In total, 84 (6.7%) of 1254 patients developed contrast-induced nephropathy: 6.2% in the ACEI\/ARB group versus 10.8% in the non-ACEI\/ARB group ( P=0.029), with an adjusted odds ratio (OR) of 0.89 (95% confidence interval (CI) 0.46\u20131.73, P=0.735). The incidence of contrast-induced nephropathy was lower in the ACEI\/ARB group than in the non-ACEI\/ARB group in the second tertile ( P=0.031), while not significantly different in the first ( P=0.701) and third ( P=0.254) tertiles. ACEIs\/ARBs were independently associated with a lower contrast-induced nephropathy risk (OR 0.26, 95% CI 0.09\u20130.74, P=0.012) and long-term all-cause death (hazard ratio 0.461, 95% CI 0.282\u20130.755, P=0.002) only in the second hydration volume to body weight tertile.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The effects of ACEIs\/ARBs on contrast-induced nephropathy risk vary according to saline hydration intensity in chronic kidney disease patients, and may further reduce contrast-induced nephropathy risk in patients administered moderate saline hydration.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1470320317708894","type":"journal-article","created":{"date-parts":[[2017,5,11]],"date-time":"2017-05-11T11:09:44Z","timestamp":1494500984000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Intensity of hydration changes the role of renin\u2013angiotensin\u2013aldosterone system blockers in contrast-induced nephropathy risk after coronary catheterisation in patients with chronic kidney disease"],"prefix":"10.1177","volume":"18","author":[{"given":"Xiao-sheng","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, 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