{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:13:27Z","timestamp":1787019207504,"version":"build-2736575974"},"reference-count":30,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Renin Angiotensin Aldosterone Syst"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Urinary angiotensinogen (uAGT) has recently been proposed as a marker of kidney injury and activated intrarenal renin\u2013angiotensin system. We investigated the effects of living donor nephrectomy on uAGT levels, blood pressure, estimated glomerular filtration rate, proteinuria and compensatory hypertrophy in the remaining kidney of living kidney donors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Twenty living kidney donors were included in the study and followed for 1 year. uAGT levels were measured with enzyme-linked immunosorbent assay preoperatively and postoperatively at the 15th day, 1, 6 and 12 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Four donors were excluded from the study due to lack of data. The mean baseline estimated glomerular filtration rate was 98 \u00b1 15 ml\/min\/1.73 m\u00b2. Serum creatinine, uAGT\/creatinine, uAGT\/protein levels were higher and estimated glomerular filtration rate was lower than baseline values at all time periods. Urinary protein\/creatinine levels increased after donor nephrectomy, but after 6 months they returned to baseline values. Renal volume increased after nephrectomy, but these changes did not show any correlation with uAGT\/creatinine, uAGT\/protein, estimated glomerular filtration rate or systolic\/diastolic blood pressures. uAGT\/creatinine at 6 months and urinary protein\/creatinine ratio at 12 months showed a positive correlation ( P=0.008, r=0.639).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>After donor nephrectomy, increasing uAGT levels can be the result of activation of the intrarenal renin\u2013angiotensin system affecting the compensatory changes in the remaining kidney. The long-term effects of increased uAGT levels on the remaining kidney should be examined more closely in future studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1470320317734082","type":"journal-article","created":{"date-parts":[[2018,1,25]],"date-time":"2018-01-25T05:53:24Z","timestamp":1516859604000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Effect of unilateral nephrectomy on urinary angiotensinogen levels in living kidney donors: 1 year follow-up study"],"prefix":"10.1177","volume":"18","author":[{"given":"Zeynep","family":"Kendi Celebi","sequence":"first","affiliation":[{"name":"Department of Nephrology, Ankara University School of Medicine, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet","family":"Peker","sequence":"additional","affiliation":[{"name":"Department of Radiology, Ankara University School of Medicine, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sim","family":"Kutlay","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Ankara University School of Medicine, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Senem","family":"Kocak","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Ankara University School of Medicine, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Acar","family":"Tuzuner","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Ankara University School of Medicine, Turkey"},{"name":"Transplantation Center, Ankara University School of Medicine, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sehsuvar","family":"Erturk","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Ankara University School of Medicine, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenan","family":"Keven","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Ankara University School of Medicine, Turkey"},{"name":"Transplantation Center, Ankara University School of Medicine, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sule","family":"Sengul","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Ankara University School of Medicine, Turkey"},{"name":"Transplantation Center, Ankara University School of Medicine, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,10,9]]},"reference":[{"key":"bibr1-1470320317734082","first-page":"432","volume":"6","author":"Harrison JH","year":"1956","journal-title":"Surg Forum"},{"key":"bibr2-1470320317734082","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfr669"},{"key":"bibr3-1470320317734082","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2015091018"},{"key":"bibr4-1470320317734082","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1681\/ASN.V4101798","volume":"4","author":"Ter Wee PM","year":"1994","journal-title":"J Am Soc Nephrol"},{"key":"bibr5-1470320317734082","doi-asserted-by":"publisher","DOI":"10.1038\/ajh.2008.35"},{"key":"bibr6-1470320317734082","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-007-7699-9_17"},{"key":"bibr7-1470320317734082","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/14.suppl_1.42"},{"key":"bibr8-1470320317734082","first-page":"11464","volume":"8","author":"Zhuang Z","year":"2015","journal-title":"Int J Clin Exp Pathol"},{"key":"bibr9-1470320317734082","doi-asserted-by":"publisher","DOI":"10.3109\/0886022X.2014.890857"},{"key":"bibr10-1470320317734082","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-011-0475-4"},{"key":"bibr11-1470320317734082","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfs011"},{"key":"bibr12-1470320317734082","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2013.02.059"},{"key":"bibr13-1470320317734082","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-150-9-200905050-00006"},{"key":"bibr14-1470320317734082","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.148.1.6344137"},{"key":"bibr15-1470320317734082","doi-asserted-by":"publisher","DOI":"10.1111\/eci.12444"},{"key":"bibr16-1470320317734082","doi-asserted-by":"publisher","DOI":"10.3109\/03009734.2014.899654"},{"key":"bibr17-1470320317734082","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2010.128"},{"key":"bibr18-1470320317734082","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2012.05.086"},{"key":"bibr19-1470320317734082","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1510491"},{"key":"bibr20-1470320317734082","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.115.06608"},{"key":"bibr21-1470320317734082","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2015.01.019"},{"key":"bibr22-1470320317734082","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2015.12.082"},{"key":"bibr23-1470320317734082","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000000356"},{"key":"bibr24-1470320317734082","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00401.2005"},{"key":"bibr25-1470320317734082","doi-asserted-by":"publisher","DOI":"10.1097\/MNH.0b013e328359dbed"},{"key":"bibr26-1470320317734082","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2004.00635.x"},{"key":"bibr27-1470320317734082","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-013-2687-z"},{"key":"bibr28-1470320317734082","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.110.164244"},{"key":"bibr29-1470320317734082","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00260.2015"},{"key":"bibr30-1470320317734082","doi-asserted-by":"publisher","DOI":"10.1172\/JCI78885"}],"container-title":["Journal of the Renin-Angiotensin-Aldosterone System"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1470320317734082","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1470320317734082","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1470320317734082","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:39:22Z","timestamp":1777509562000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1470320317734082"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["10.1177\/1470320317734082"],"URL":"https:\/\/doi.org\/10.1177\/1470320317734082","relation":{},"ISSN":["1470-3203","1752-8976"],"issn-type":[{"value":"1470-3203","type":"print"},{"value":"1752-8976","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10]]},"article-number":"1470320317734082"}}