{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T01:58:24Z","timestamp":1777859904321,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Renin Angiotensin Aldosterone Syst"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>\n                      In our recent study, non-Gaussianity of heart rate variability (\u03bb\n                      <jats:sub>25s<\/jats:sub>\n                      ), an indicator of sympathetic nerve activity, did not change during two-day treatment with the angiotensin II type 1 receptor blocker (ARB) azilsartan. Coadministration of calcium channel blockers (CCBs) might affect the study results.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      In this subanalysis, 20 patients with chronic kidney disease (14 men; age 61\u00b115 years) were divided into three groups: patients with coadministration of L-type CCB, patients without coadministration of CCB, and patients with coadministration of sympathoinhibitory (L\/T- or L\/T\/N-type) CCB. \u03bb\n                      <jats:sub>25s<\/jats:sub>\n                      was calculated separately in daytime and nighttime.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Daytime \u03bb\n                      <jats:sub>25s<\/jats:sub>\n                      at baseline was higher in patients with L-type CCB coadministration (0.62\u00b10.18, n = 5) compared with those without CCB (0.49\u00b10.13, n = 11) and those with sympathoinhibitory CCB (0.46\u00b10.06, n = 4). The relationship between the changes in daytime \u03bb\n                      <jats:sub>25s<\/jats:sub>\n                      and systolic blood pressure was positive in patients with L-type CCB coadministration, whereas the relationship was inverse in the other two groups. A larger decrease in daytime \u03bb\n                      <jats:sub>25s<\/jats:sub>\n                      was shown in patients with L-type CCB coadministration compared with those in the other two groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>CCBs, as well as diuretics, are recommended as second-line antihypertensive agents. Our results suggested that ARBs can overwhelm the activation of sympathetic nerve activity stimulated by coadministration of L-type CCBs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1470320319839525","type":"journal-article","created":{"date-parts":[[2019,3,27]],"date-time":"2019-03-27T16:44:49Z","timestamp":1553705089000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["The angiotensin II type 1 receptor blocker azilsartan can overwhelm the sympathetic nerve activation stimulated by coadministration of calcium channel blockers"],"prefix":"10.1177","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7455-5776","authenticated-orcid":false,"given":"Michio","family":"Fukuda","sequence":"first","affiliation":[{"name":"Department of Cardio-Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukako","family":"Isobe-Sasaki","sequence":"additional","affiliation":[{"name":"Department of Cardio-Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryo","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Cardio-Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiyuki","family":"Miura","sequence":"additional","affiliation":[{"name":"Department of Cardio-Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masashi","family":"Mizuno","sequence":"additional","affiliation":[{"name":"Department of Cardio-Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minamo","family":"Ono","sequence":"additional","affiliation":[{"name":"Department of Cardio-Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"Kiyono","sequence":"additional","affiliation":[{"name":"Department of Mechanical Science and Bioengineering, Osaka University, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiharu","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Physical and Health Education, University of Tokyo Graduate School of Education, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junichiro","family":"Hayano","sequence":"additional","affiliation":[{"name":"Department of Medical Education, Nagoya City University Graduate School of Medical Sciences, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuyuki","family":"Ohte","sequence":"additional","affiliation":[{"name":"Department of Cardio-Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences, 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