{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T01:58:41Z","timestamp":1777859921793,"version":"3.51.4"},"reference-count":46,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81700637"],"award-info":[{"award-number":["81700637"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the Natural Science Foundation of Liaoning Province","award":["20170540993"],"award-info":[{"award-number":["20170540993"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Renin Angiotensin Aldosterone Syst"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The purpose of this study was to systematically evaluate the effect of renin\u2013angiotensin\u2013aldosterone system blockers on the incidence of contrast-induced nephropathy in patients undergoing coronary angiography or percutaneous coronary intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A systematic literature search of several databases was conducted to identify studies that met the inclusion criteria. A total of 12 studies with 14 trials that performed studies on a total of 4864 patients (2484 treated with renin\u2013angiotensin\u2013aldosterone system blockers and 2380 in the control group) were included. The primary endpoint was the overall incidence of contrast-induced nephropathy. Analyses were performed with STATA version 12.0.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The overall contrast-induced nephropathy incidence in renin\u2013angiotensin\u2013aldosterone system blocker and control groups was 10.43% and 6.81%, respectively. The pooled relative risk of contrast-induced nephropathy incidence was 1.22 (95% confidence interval: 0.81\u20131.84) in the renin\u2013angiotensin\u2013aldosterone system blocker group. An increased risk of developing contrast-induced nephropathy in the renin\u2013angiotensin\u2013aldosterone system blocker group was observed among older people, non-Asians, chronic users, and studies with larger sample size, and the pooled RRs and 95% confidence intervals were 2.02 (1.21\u20133.36), 2.30 (1.41\u20133.76), 1.69 (1.10\u20132.59) and 1.83 (1.28\u20132.63), respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Intervention with renin\u2013angiotensin\u2013aldosterone system blockers was associated with an increased risk of contrast-induced nephropathy among non-Asians, chronic users, older people, and studies with larger sample size. Large clinical trials with strict inclusion criteria are needed to confirm our results and to evaluate the effect further.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1470320320919587","type":"journal-article","created":{"date-parts":[[2020,5,6]],"date-time":"2020-05-06T01:57:28Z","timestamp":1588730248000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Meta-analysis of effect of renin\u2013angiotensin\u2013aldosterone system blockers on contrast-induced nephropathy"],"prefix":"10.1177","volume":"21","author":[{"given":"Weidong","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Nephrology, The First Hospital of China Medical University, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Qu","sequence":"additional","affiliation":[{"name":"Department of Nephrology, The First Hospital of China Medical University, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Nephrology, The First Hospital of China Medical University, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9112-1032","authenticated-orcid":false,"given":"Xiaodan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Nephrology, The First Hospital of China Medical University, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,5,5]]},"reference":[{"key":"bibr1-1470320320919587","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.116.004498"},{"key":"bibr2-1470320320919587","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.11.170"},{"key":"bibr3-1470320320919587","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.h4395"},{"key":"bibr4-1470320320919587","doi-asserted-by":"publisher","DOI":"10.1177\/0003319718803677"},{"key":"bibr5-1470320320919587","first-page":"205","volume-title":"Crit Care","volume":"17","author":"Lameire N","year":"2013"},{"key":"bibr6-1470320320919587","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-148-4-200802190-00007"},{"key":"bibr7-1470320320919587","doi-asserted-by":"publisher","DOI":"10.1177\/0003319714550309"},{"key":"bibr8-1470320320919587","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13456"},{"key":"bibr9-1470320320919587","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/423848"},{"key":"bibr10-1470320320919587","doi-asserted-by":"publisher","DOI":"10.1016\/j.carrev.2010.01.002"},{"key":"bibr11-1470320320919587","first-page":"2917","volume":"96","author":"Liang DL","year":"2016","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"bibr12-1470320320919587","doi-asserted-by":"publisher","DOI":"10.5301\/jn.5000059"},{"key":"bibr13-1470320320919587","first-page":"432","volume":"6","author":"Spatz C","year":"2012","journal-title":"Iran J Kidney Dis"},{"key":"bibr14-1470320320919587","doi-asserted-by":"publisher","DOI":"10.1016\/0197-2456(95)00134-4"},{"key":"bibr15-1470320320919587","unstructured":"Wells GA, Shea B, O\u2019Connell D, et al. 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