{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T01:58:42Z","timestamp":1777859922818,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"This study was supported by grants from the German Federal Ministry of Education and Research within the Center for Sepsis Control and Care","award":["(grant 01EO1002, Project D1.3"],"award-info":[{"award-number":["(grant 01EO1002, Project D1.3"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Renin Angiotensin Aldosterone Syst"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>The angiotensin converting enzyme inhibitor ramipril is a standard antihypertensive therapy for many patients. Because angiotensin II may promote inflammation, we were interested in whether basal pretreatment with ramipril may modify renal function and inflammation as well as systemic outcome in experimentally induced sepsis in mice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and methods:<\/jats:title>\n                    <jats:p>Ramipril (10 mg\/kg\/day) pretreatment or placebo (NaCl) was given intraperitoneally for 5 days to C57BL6\/J mice, followed by either sham operation or cecal ligation and puncture sepsis induction. Real-time polymerase chain reaction and immunological stains were used to evaluate renal gene and protein expression, respectively. Plasma creatinine, neutrophil-gelatinase associated lipocalin, and blood urea nitrogen were used as markers for renal function. A clinical severity score was determined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Administration of ramipril before cecal ligation and puncture surgery was associated with reduced renal inflammation but did not improved renal function and structure and even worsened the clinical status of septic mice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The data suggest that the effects of ramipril pretreatment are complex. Additional studies including monitoring of hemodynamic parameters are necessary to elucidate the exact mechanism(s) of this observation. In addition, the timing of the ramipril administration could be of importance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1470320320923977","type":"journal-article","created":{"date-parts":[[2020,5,16]],"date-time":"2020-05-16T05:54:04Z","timestamp":1589608444000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Ramipril pretreatment worsened renal injury and survival despite a reduction in renal inflammation in experimentally induced sepsis in mice"],"prefix":"10.1177","volume":"21","author":[{"given":"Tzvetanka","family":"Bondeva","sequence":"first","affiliation":[{"name":"Department of Internal Medicine III, Jena University Hospital, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katrin","family":"Schindler","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, Jena University Hospital, Germany"},{"name":"Institute of Human genetic, Jena University Hospital, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Schindler","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, Jena University Hospital, Germany"},{"name":"Department of Experimental Surgery, Jena University Hospital, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3291-0610","authenticated-orcid":false,"given":"Gunter","family":"Wolf","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, Jena University Hospital, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,5,16]]},"reference":[{"key":"bibr1-1470320320923977","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000003654"},{"key":"bibr2-1470320320923977","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000001382."},{"key":"bibr3-1470320320923977","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-009-1545-x"},{"key":"bibr4-1470320320923977","doi-asserted-by":"publisher","DOI":"10.1111\/j.0001-5172.2004.00283.x"},{"key":"bibr5-1470320320923977","doi-asserted-by":"publisher","DOI":"10.1097\/00024382-200013020-00004"},{"key":"bibr6-1470320320923977","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2008.214"},{"key":"bibr7-1470320320923977","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2011.05.019"},{"key":"bibr8-1470320320923977","doi-asserted-by":"publisher","DOI":"10.1006\/meth.2001.1262"},{"key":"bibr9-1470320320923977","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfv442"},{"key":"bibr10-1470320320923977","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfx202"},{"key":"bibr11-1470320320923977","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-018-0826-4"},{"key":"bibr12-1470320320923977","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfi265"},{"key":"bibr13-1470320320923977","doi-asserted-by":"publisher","DOI":"10.1080\/15384101.2018.1542901"},{"key":"bibr14-1470320320923977","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000000397"},{"key":"bibr15-1470320320923977","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12419"},{"key":"bibr16-1470320320923977","doi-asserted-by":"publisher","DOI":"10.1097\/MCC.0000000000000153"},{"key":"bibr17-1470320320923977","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006040356"},{"key":"bibr18-1470320320923977","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119615"},{"key":"bibr19-1470320320923977","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-018-0900-0"},{"key":"bibr20-1470320320923977","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2005070699"}],"container-title":["Journal 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