{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T15:01:14Z","timestamp":1782831674827,"version":"3.54.5"},"reference-count":19,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"The National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81670785"],"award-info":[{"award-number":["81670785"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"The National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81800701"],"award-info":[{"award-number":["81800701"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"The National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81800731"],"award-info":[{"award-number":["81800731"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"The National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81970720"],"award-info":[{"award-number":["81970720"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"The National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81870567"],"award-info":[{"award-number":["81870567"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National key research & development plan, major project of precision medicine research","award":["2017YFC0909600, sub-project: 2017YFC0909602,2017"],"award-info":[{"award-number":["2017YFC0909600, sub-project: 2017YFC0909602,2017"]}]},{"name":"Joint Research Project of Chongqing Science and Technology Commission and Traditional Chinese Medicine","award":["MSXM20192015"],"award-info":[{"award-number":["MSXM20192015"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Renin Angiotensin Aldosterone Syst"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>This study aimed to investigate the effect of anti-osteoporosis therapy on plasma aldosterone concentration (PAC), plasma renin concentration (PRC) and the aldosterone\/renin ratio (ARR) in patients with postmenopausal osteoporosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In 60 patients with postmenopausal osteoporosis, bone mineral density (BMD), PAC and PRC were measured before and after treatment with alendronate (70 mg\/week, n=22) or recombinant human parathyroid hormone (20 \u03bcg\/day, n=35) for 48 weeks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>PAC was negatively correlated with the T-score of lumbar spine BMD and femoral neck BMD (lumbar r=\u22120.386, p&lt;0.01; femoral neck r=\u22120.262, p&lt;0.05). With the improvement in lumbar BMD after anti-osteoporosis treatment (T-score \u22123.4\u00b10.5 vs. \u20133.1 \u00b10.4, p&lt;0.0001), PAC decreased from 182.8\u00b153.2 to 143.7\u00b168.6 pg\/mL ( p&lt;0.0001), PRC increased from 7.8\u00b111.6 to 39.2\u00b150.0 \u03bcIU\/mL ( p&lt;0.0001) and the ARR decreased from 74.8\u00b175.2 to 13.1\u00b117.1 pg\/\u03bcIU ( p&lt;0.0001). At baseline, 58% (35\/60) of the patients had an ARR &gt;37 pg\/\u03bcIU, and the proportion decreased to 8% (5\/57) after treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Treatment with alendronate or parathyroid hormone causes decreased PAC and increased PRC, resulting in a decreased ARR in postmenopausal women with osteoporosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1470320320928874","type":"journal-article","created":{"date-parts":[[2020,6,2]],"date-time":"2020-06-02T01:35:38Z","timestamp":1591061738000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Effects of anti-osteoporosis therapy on plasma aldosterone and renin"],"prefix":"10.1177","volume":"21","author":[{"given":"Qingfen","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Endocrinology, the People\u2019s Hospital of Kaizhou District, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kangla","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Cardiology, the First Affiliated Hospital of Chongqing Medical University, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longwei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, the People\u2019s Hospital of Kaizhou District, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Shu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, the Affiliated Hospital of Guizhou Medical University, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3294-268X","authenticated-orcid":false,"given":"Zhixin","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, the First Affiliated Hospital of Chongqing Medical University, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuyang","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, the People\u2019s Hospital of Kaizhou District, PR China"},{"name":"Department of Emergency, the Second People\u2019s Hospital of Guiyang, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qifu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, the First Affiliated Hospital of Chongqing Medical University, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shumin","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, the First Affiliated Hospital of Chongqing Medical University, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,6,1]]},"reference":[{"key":"bibr1-1470320320928874","doi-asserted-by":"publisher","DOI":"10.1038\/550S15a"},{"key":"bibr2-1470320320928874","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-009-0925-y"},{"key":"bibr3-1470320320928874","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.36.5.780"},{"key":"bibr4-1470320320928874","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.01.052"},{"key":"bibr5-1470320320928874","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.07.059"},{"key":"bibr6-1470320320928874","doi-asserted-by":"publisher","DOI":"10.1038\/s41371-018-0069-7"},{"key":"bibr7-1470320320928874","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015-4061"},{"key":"bibr8-1470320320928874","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.117.10197"},{"key":"bibr9-1470320320928874","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-4440"},{"key":"bibr10-1470320320928874","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650090802"},{"key":"bibr11-1470320320928874","doi-asserted-by":"publisher","DOI":"10.1080\/09513590600850300"},{"key":"bibr12-1470320320928874","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0594.2009.00562.x"},{"key":"bibr13-1470320320928874","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.333"},{"key":"bibr14-1470320320928874","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.111.173948"},{"key":"bibr15-1470320320928874","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19910215)67:4<984::AID-CNCR2820670421>3.0.CO;2-0"},{"key":"bibr16-1470320320928874","doi-asserted-by":"publisher","DOI":"10.1210\/endo-129-1-489"},{"key":"bibr17-1470320320928874","first-page":"360","volume":"2","author":"Hulter 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