{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T01:58:50Z","timestamp":1777859930296,"version":"3.51.4"},"reference-count":32,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Joint Medical Research Project of Chongqing Science and Technology Commission & Chongqing Health and Family Planning Commission","award":["Youth Project, 2018QNXM001"],"award-info":[{"award-number":["Youth Project, 2018QNXM001"]}]},{"DOI":"10.13039\/501100001809","name":"national natural science foundation of china","doi-asserted-by":"publisher","award":["81670785, 81700754, 81870567, 81800731, 81800701"],"award-info":[{"award-number":["81670785, 81700754, 81870567, 81800731, 81800701"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Outstanding Talents of the First Affiliated Hospital of Chongqing Medical University 2019."}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Renin Angiotensin Aldosterone Syst"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>To compare the effect of surgical or medical treatment on the risk of cardiovascular diseases (CVD) and all-cause mortality in patients with established primary aldosteronism (PA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We searched PUBMED, MEDLINE and Cochrane Library for the meta-analysis. We included patients who were diagnosed with PA following guideline-supported protocols and received surgery or mineralocorticoid receptor antagonist (MRA)-based medical treatment, and age-sex matched patients with treated essential hypertension (EH). Primary endpoints were CVD incidence and all-cause mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Compared with EH, patients with treated PA had a higher risk of CVD [odds ratio (OR) 1.79; 95% confidence interval (CI) 1.39\u20132.31]. This elevated risk was only observed in patients with medically treated PA [OR 2.11; 95%CI 1.88\u20132.38] but not in those with surgically treated PA. The risk of all-cause mortality was significantly lower in patients with treated PA [OR 0.86; 95% CI 0.77\u20130.95] compared to EH. The reduced risk was only observed in patients with surgically treated PA [OR 0.47; 95% CI 0.34\u20130.66], but not in those with medically treated PA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Patients with medically treated PA have a higher risk of CVD compared to patients with EH. Surgical treatment of PA reduces the risk of CVD and all-cause mortality in patients with PA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/14703203211003781","type":"journal-article","created":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T02:11:56Z","timestamp":1616465516000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":22,"title":["Cardiovascular events and all-cause mortality in surgically or medically treated primary aldosteronism: A Meta-analysis"],"prefix":"10.1177","volume":"22","author":[{"given":"Ying","family":"Jing","sequence":"first","affiliation":[{"name":"Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kangla","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruolin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shumin","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenwen","family":"He","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6958-7677","authenticated-orcid":false,"given":"Kanran","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Yang","sequence":"additional","affiliation":[{"name":"Centre for Endocrinology and Metabolism, Hudson Institute of Medical Research, Clayton, VIC, Australia"},{"name":"Department of Medicine, Monash University, Clayton, VIC, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qifu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2925-0583","authenticated-orcid":false,"given":"Jinbo","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,3,22]]},"reference":[{"key":"bibr1-14703203211003781","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015-4061"},{"key":"bibr2-14703203211003781","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2005.02.010"},{"key":"bibr3-14703203211003781","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000001361"},{"key":"bibr4-14703203211003781","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.117.10596"},{"key":"bibr5-14703203211003781","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(17)30367-4"},{"key":"bibr6-14703203211003781","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2007.33"},{"key":"bibr7-14703203211003781","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.112.197111"},{"key":"bibr8-14703203211003781","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-0104"},{"key":"bibr9-14703203211003781","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.EJ11-0133"},{"key":"bibr10-14703203211003781","volume-title":"Cochrane handbook for systematic reviews of interventions","author":"Higgins JPT","year":"2021"},{"key":"bibr11-14703203211003781","unstructured":"Wells GA, Shea B, O\u2019Connell D, et al. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses, http:\/\/www.ohri.ca\/programs\/clinical_epidemiology\/oxford.asp (accessed 20 April 2018)."},{"key":"bibr12-14703203211003781","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2700"},{"key":"bibr13-14703203211003781","doi-asserted-by":"publisher","DOI":"10.1016\/j.cct.2015.09.002"},{"key":"bibr14-14703203211003781","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1186"},{"key":"bibr15-14703203211003781","doi-asserted-by":"publisher","DOI":"10.1016\/0197-2456(86)90046-2"},{"key":"bibr16-14703203211003781","first-page":"719","volume":"22","author":"Mantel N","year":"1959","journal-title":"J Natl Cancer Inst"},{"key":"bibr17-14703203211003781","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4780060325"},{"key":"bibr18-14703203211003781","doi-asserted-by":"publisher","DOI":"10.1186\/1752-0509-6-S3-S11"},{"key":"bibr19-14703203211003781","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.315.7109.629"},{"key":"bibr20-14703203211003781","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-9-80"},{"key":"bibr21-14703203211003781","doi-asserted-by":"publisher","DOI":"10.1210\/js.2019-00019"},{"key":"bibr22-14703203211003781","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2012.08.025"},{"key":"bibr23-14703203211003781","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-2805"},{"key":"bibr24-14703203211003781","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(17)30319-4"},{"key":"bibr25-14703203211003781","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-2204"},{"key":"bibr26-14703203211003781","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000000284"},{"key":"bibr27-14703203211003781","doi-asserted-by":"publisher","DOI":"10.1055\/s-0042-103588"},{"key":"bibr28-14703203211003781","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2019.06.055"},{"key":"bibr29-14703203211003781","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(17)30135-3"},{"key":"bibr30-14703203211003781","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1295412"},{"key":"bibr31-14703203211003781","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.113.01316"},{"key":"bibr32-14703203211003781","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-2055"}],"container-title":["Journal of the Renin-Angiotensin-Aldosterone System"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/14703203211003781","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/14703203211003781","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/14703203211003781","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:40:02Z","timestamp":1777509602000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/14703203211003781"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1177\/14703203211003781"],"URL":"https:\/\/doi.org\/10.1177\/14703203211003781","relation":{},"ISSN":["1470-3203","1752-8976"],"issn-type":[{"value":"1470-3203","type":"print"},{"value":"1752-8976","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1]]},"article-number":"14703203211003781"}}