{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:42:32Z","timestamp":1777725752960,"version":"3.51.4"},"reference-count":15,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2002,4,1]],"date-time":"2002-04-01T00:00:00Z","timestamp":1017619200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2002,4]]},"abstract":"<jats:p>Safety and tolerability of sildenafil citrate was assessed in a population subset of 60 Singaporean men with erectile dysfunction taken from the Asian Sildenafil Efficacy and Safety Study (ASSESS-I), a double-blind, placebo-controlled, flexible-dose study. The men, from two centres, with \u2265 6 months' history of erectile dysfunction, were randomized to two treatment arms for 12 weeks. One group (30 patients) received sildenafil (initial dose 50 mg taken 1 h before sexual activity for the first 2 weeks, increased to 100 mg or decreased to 25 mg, according to efficacy and\/or tolerability). The remaining 30 patients received a matching placebo. Incidence and type of adverse effects were evaluated at 2, 4, 8 and 12 weeks. Nine patients (30.0%) on sildenafil (33.1% in the full ASSESS-I study) and one patient (3.3%) on placebo (22.8% in the full ASSESS-I study) experienced treatment-related adverse events, the most frequent being headache in the sildenafil group (reported by five patients [16.7%]; 11.0% in the full ASSESS-I study). Flushing, visual disturbance, dizziness, insomnia, myalgia and back pain each occurred in one patient in the sildenafil group (3.3%); in the placebo group, one patient (3.3%) had headache. Importantly, the incidence of cardiovascular and respiratory system adverse events were relatively less than in the full ASSESS-I population (cardiovascular 3.3% in the present study versus 10.2% in the full ASSESS-I population; respiratory 3.3% versus 5.5%). All adverse events were transient and mild, and did not lead to treatment withdrawal. There was no effect on sitting blood pressure, heart rate or standard laboratory parameters; more importantly, there was no incidence of myocardial infarction, stroke or priapism. These results should reassure Singaporean patients and their physicians of the safety of sildenafil for erectile dysfunction.<\/jats:p>","DOI":"10.1177\/147323000203000206","type":"journal-article","created":{"date-parts":[[2013,2,27]],"date-time":"2013-02-27T14:22:28Z","timestamp":1361974948000},"page":"137-143","source":"Crossref","is-referenced-by-count":7,"title":["Clinical Safety Profile of Sildenafil in Singaporean Men with Erectile Dysfunction: Pre-Marketing Experience (ASSESS-I Evaluation)"],"prefix":"10.1177","volume":"30","author":[{"given":"PHC","family":"Lim","sequence":"first","affiliation":[{"name":"Department of Urology, Changi General Hospital, Singapore;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"FC","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Urology, Changi General Hospital, Singapore;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CWS","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Urology, Singapore General Hospital, Singapore;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MYC","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Urology, Singapore General Hospital, Singapore;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CTY","family":"Chee","sequence":"additional","affiliation":[{"name":"Department of Urology, Singapore General Hospital, Singapore;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Moorthy","sequence":"additional","affiliation":[{"name":"Department of Urology, Changi General Hospital, Singapore;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SS","family":"Vasan","sequence":"additional","affiliation":[{"name":"Private Practice, Bangalore, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2002,4,1]]},"reference":[{"key":"bibr1-147323000203000206","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)34871-1"},{"key":"bibr2-147323000203000206","first-page":"248","volume":"21","author":"Lim PHC","year":"1992","journal-title":"Ann Acad Med Singapore"},{"key":"bibr3-147323000203000206","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199805143382001"},{"key":"bibr4-147323000203000206","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410X.1996.10220.x"},{"key":"bibr5-147323000203000206","first-page":"S46","volume":"9","author":"Lue TF","year":"1997","journal-title":"Int J Impot Res"},{"key":"bibr6-147323000203000206","first-page":"S46","volume":"9","author":"Hodges M","year":"1997","journal-title":"Int J Impot Res"},{"key":"bibr7-147323000203000206","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijir.3900354"},{"key":"bibr8-147323000203000206","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(00)00688-9"},{"key":"bibr9-147323000203000206","doi-asserted-by":"publisher","DOI":"10.1046\/j.1442-2042.2002.00425.x"},{"key":"bibr10-147323000203000206","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1993.03510010089036"},{"key":"bibr11-147323000203000206","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod52.3.485"},{"key":"bibr12-147323000203000206","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.316.7132.678"},{"key":"bibr13-147323000203000206","first-page":"47","volume":"8","author":"Boolell M","year":"1996","journal-title":"Int J Impot Res"},{"key":"bibr14-147323000203000206","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-7061(00)01177-8"},{"key":"bibr15-147323000203000206","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(00)00705-1"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/147323000203000206","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/147323000203000206","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:43:18Z","timestamp":1777459398000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/147323000203000206"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,4]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2002,4]]}},"alternative-id":["10.1177\/147323000203000206"],"URL":"https:\/\/doi.org\/10.1177\/147323000203000206","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,4]]}}}