{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:42:52Z","timestamp":1777725772169,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2002,6,1]],"date-time":"2002-06-01T00:00:00Z","timestamp":1022889600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2002,6]]},"abstract":"<jats:p>The efficacy and safety profiles of barnidipine in the treatment of hypertension were evaluated in an open parallel-group study. Fifty-nine Chinese patients with mild-to-moderate essential hypertension were randomized to receive either barnidipine or felodipine (5 mg once daily, titrated to 10 mg or 15 mg once daily, as indicated) for 12 weeks. Both drugs reduced blood pressures significantly with \u2265 68% of cases obtaining marked or moderate blood pressure reduction. Mean reductions in systolic and diastolic blood pressure for barnidipine treatment were 23.7 \u00b1 13.5 mmHg and 12.7 \u00b1 7.9 mmHg, and for felodipine, 24.3 \u00b1 18.4 mmHg and 14.5 \u00b1 10.0 mmHg, respectively. There was no significant difference between these two drugs in anti-hypertensive effect, heart rate, laboratory measurements or incidence of adverse events. The only difference was that more patients taking felodipine experienced palpitations. We conclude that barnidipine has similar efficacy and a similar safety profile to felodipine in the treatment of mild-to-moderate essential hypertension in Chinese patients.<\/jats:p>","DOI":"10.1177\/147323000203000317","type":"journal-article","created":{"date-parts":[[2013,2,27]],"date-time":"2013-02-27T14:22:28Z","timestamp":1361974948000},"page":"330-336","source":"Crossref","is-referenced-by-count":9,"title":["Efficacy and Safety of Barnidipine Compared with Felodipine in the Treatment of Hypertension in Chinese Patients"],"prefix":"10.1177","volume":"30","author":[{"given":"CS","family":"Liau","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan, Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KL","family":"Chien","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan, Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CL","family":"Chao","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan, Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TM","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan, Republic of 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