{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:42:56Z","timestamp":1777725776960,"version":"3.51.4"},"reference-count":37,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2002,8,1]],"date-time":"2002-08-01T00:00:00Z","timestamp":1028160000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2002,8]]},"abstract":"<jats:p>\n                    The aim of the present study was to investigate whether CYP2C19 polymorphism status and gastric emptying are related to healing in patients with gastric ulcers. We studied the CYP2C19 status in seven patients with proton pump inhibitor (PPI)-resistant ulcers, 21 with PPI-sensitive ulcers and 46 healthy volunteers using polymerase chain reaction restriction fragment length polymorphism to detect CYP2C19m1 mutation in exon 5 and CYP2C19m2 mutation in exon 4. Gastric emptying was evaluated using the\n                    <jats:sup>13<\/jats:sup>\n                    C-acetate breath test. The frequency of phenotypes, indicated by genotypes, did not differ significantly between the three patient groups. The peak time of\n                    <jats:sup>13<\/jats:sup>\n                    C excretion in patients with PPI-resistant ulcers was significantly longer than that of patients with PPI-sensitive ulcers and healthy volunteers. Our results suggest that rate of gastric emptying, but not CYP2C19 polymorphism, is likely to be an important factor in the delayed healing of patients with PPI-resistant gastric ulcer.\n                  <\/jats:p>","DOI":"10.1177\/147323000203000408","type":"journal-article","created":{"date-parts":[[2013,2,27]],"date-time":"2013-02-27T14:22:28Z","timestamp":1361974948000},"page":"413-421","source":"Crossref","is-referenced-by-count":6,"title":["Polymorphism of\n                    <i>CYP2C19<\/i>\n                    and Gastric Emptying in Patients with Proton Pump Inhibitor-Resistant Gastric Ulcers"],"prefix":"10.1177","volume":"30","author":[{"given":"F","family":"Wada","sequence":"first","affiliation":[{"name":"Second Department of Internal Medicine, Nagasaki University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Murase","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine, Nagasaki University 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