{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:56:23Z","timestamp":1791312983589,"version":"4.3.1"},"reference-count":19,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2002,10,1]],"date-time":"2002-10-01T00:00:00Z","timestamp":1033430400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2002,10]]},"abstract":"<jats:p>\n                    Leptospirosis can present with a wide clinical spectrum, and haematological manifestations are often apparent. We retrospectively analysed platelet counts in 49 patients with leptospirosis. Forty-three patients (87.8%) had thrombocytopenia. Mean baseline platelet counts rose from 69 \u00d7 10\n                    <jats:sup>9<\/jats:sup>\n                    \/l to 151 \u00d7 10\n                    <jats:sup>9<\/jats:sup>\n                    \/l following treatment. Haemorrhagic episodes were observed in 11 patients. Platelet nadir was 29 \u00d7 10\n                    <jats:sup>9<\/jats:sup>\n                    \/l in the group experiencing bleeding and 64 \u00d7 10\n                    <jats:sup>9<\/jats:sup>\n                    \/l in the remainder. Six patients died due to bleeding and one due to sepsis. Thirty-six patients (73.5%) had acute renal failure; their mean platelet count was 46 \u00d7 10\n                    <jats:sup>9<\/jats:sup>\n                    \/l. Liver enzyme levels were elevated in all patients. Thrombocyte count, liver enzyme levels and bilirubin levels were significantly correlated. Forty-three (87.8%) patients showed signs of sepsis; mean thrombocyte count was 46 \u00d7 10\n                    <jats:sup>9<\/jats:sup>\n                    \/l in these patients, and 133 \u00d7 10\n                    <jats:sup>9<\/jats:sup>\n                    \/l in those without sepsis. Multiple organ involvement and fulminant disease is usually associated with renal failure and\/or thrombocytopenia in leptospirosis.\n                  <\/jats:p>","DOI":"10.1177\/147323000203000511","type":"journal-article","created":{"date-parts":[[2013,2,27]],"date-time":"2013-02-27T14:22:28Z","timestamp":1361974948000},"page":"535-540","source":"Crossref","is-referenced-by-count":22,"title":["Thrombocytopenia Complicating the Clinical Course of Leptospiral Infection"],"prefix":"10.1177","volume":"30","author":[{"given":"M","family":"Turgut","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Ondokuz Mayis University School of Medicine, Samsun, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"S\u00fcnb\u00fcl","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology and Infectious Diseases, Ondokuz Mayis University School of Medicine, Samsun, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Bayirli","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology and Infectious Diseases, Ondokuz Mayis University School of Medicine, Samsun, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Bilge","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Ondokuz Mayis University School of Medicine, Samsun, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Leblebicio\u011flu","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology and Infectious Diseases, Ondokuz Mayis University School of Medicine, Samsun, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130","family":"Haznedaro\u011flu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hacettepe University School of Medicine, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2002,10,1]]},"reference":[{"key":"bibr1-147323000203000511","doi-asserted-by":"publisher","DOI":"10.1023\/A:1007300514760"},{"key":"bibr2-147323000203000511","first-page":"27","volume":"39","author":"Edwards CN","year":"1990","journal-title":"West Indian Med J"},{"key":"bibr3-147323000203000511","doi-asserted-by":"publisher","DOI":"10.1016\/S0248-8663(88)80012-2"},{"key":"bibr4-147323000203000511","doi-asserted-by":"publisher","DOI":"10.1590\/S0036-46651990000400004"},{"key":"bibr5-147323000203000511","doi-asserted-by":"publisher","DOI":"10.1590\/S0036-46651989000200002"},{"key":"bibr6-147323000203000511","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.42.4.439"},{"key":"bibr7-147323000203000511","first-page":"1315","volume":"17","author":"Law-Koune JD","year":"1988","journal-title":"Presse Med"},{"key":"bibr8-147323000203000511","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1986.35.352"},{"key":"bibr9-147323000203000511","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1983.32.1464"},{"key":"bibr10-147323000203000511","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1982.31.827"},{"key":"bibr11-147323000203000511","doi-asserted-by":"publisher","DOI":"10.1055\/s-2001-16692"},{"key":"bibr12-147323000203000511","doi-asserted-by":"publisher","DOI":"10.1007\/s001340051252"},{"key":"bibr13-147323000203000511","first-page":"277","volume":"22","author":"Higgins R","year":"1981","journal-title":"Can Vet J"},{"key":"bibr14-147323000203000511","first-page":"174","volume":"41","author":"Higgins R","year":"1977","journal-title":"Can J Comp Med"},{"key":"bibr15-147323000203000511","unstructured":"S\u00fcnb\u00fcl M, Leblebicio\u011flu H, Esen \u015e, Aydo\u011fan S, G\u00fcnayd\u0131n M, Ero\u011flu C: Leptospirozisli hastalarda sepsis bulgular\u0131n\u0131n de\u011ferlendiril-mesi ve mortalite ile ili\u015fkisi. X. T\u00fcrk Klinik Mikrobiyoloji ve \u0130nfeksiyon Hastal\u0131klar\u0131 Kongresi (Abstract). 10th Congress of the Turkish Clinical Microbiology and Infectious Diseases, 15\u201319 October 2001, Adana, Turkey"},{"key":"bibr16-147323000203000511","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/16.suppl_5.73"},{"key":"bibr17-147323000203000511","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.43.11.961-c"},{"key":"bibr18-147323000203000511","doi-asserted-by":"publisher","DOI":"10.1023\/A:1014494012062"},{"key":"bibr19-147323000203000511","first-page":"487","volume":"53","author":"Winearls CG","year":"1984","journal-title":"Q J Med"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/147323000203000511","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/147323000203000511","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:43:31Z","timestamp":1777459411000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/147323000203000511"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,10]]},"references-count":19,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2002,10]]}},"alternative-id":["10.1177\/147323000203000511"],"URL":"https:\/\/doi.org\/10.1177\/147323000203000511","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,10]]}}}