{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:42:29Z","timestamp":1777725749018,"version":"3.51.4"},"reference-count":36,"publisher":"SAGE Publications","issue":"1_suppl","license":[{"start":{"date-parts":[[2002,2,1]],"date-time":"2002-02-01T00:00:00Z","timestamp":1012521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2002,2]]},"abstract":"<jats:p>The emergence of beta-lactamase-mediated resistance to established beta-lactam antibiotics prompted the development of beta-lactamase inhibitors for co-administration. Ampicillin has been combined with sulbactam for both parenteral and oral (as the mutual pro-drug sultamicillin) administration. The combination is active in vitro against a wide variety of Gram-positive and Gram-negative pathogens, including aerobic and anaerobic organisms. In clinical trials, ampicillin\/sulbactam has proved clinically and bacteriologically effective against a variety of frequently encountered pediatric infections, including mild-to-moderate upper respiratory tract infections (acute otitis media, sinusitis, pharyngitis, and tonsillitis), severe postoperative and intra-abdominal infections, periorbital infections (which, left untreated, can lead to blindness, brain abscess, or death), acute epiglottitis, bacterial meningitis, and brain abscess. Ampicillin\/sulbactam has also proved effective in the prevention of post-operative surgical infections in pediatric patients. The clinical efficacy profile of ampicillin\/sulbactam and sultamicillin, combined with their excellent tolerability profile, make these agents attractive options for the management of many life-threatening infections in pediatric patients.<\/jats:p>","DOI":"10.1177\/14732300020300s104","type":"journal-article","created":{"date-parts":[[2013,2,27]],"date-time":"2013-02-27T14:22:28Z","timestamp":1361974948000},"page":"20A-30A","source":"Crossref","is-referenced-by-count":12,"title":["Experience with Ampicillin\/Sulbactam in Severe Infections"],"prefix":"10.1177","volume":"30","author":[{"given":"G","family":"Kanra","sequence":"first","affiliation":[{"name":"Department of Pediatric Infectious Diseases, Hacettepe University School of Medicine, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2002,2,1]]},"reference":[{"key":"bibr1-14732300020300S104","first-page":"18","volume":"9","author":"Schito GC","year":"1997","journal-title":"J Chemother"},{"key":"bibr2-14732300020300S104","first-page":"17","volume":"5","author":"Lode H","year":"1989","journal-title":"APMIS Suppl"},{"key":"bibr3-14732300020300S104","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199803001-00003"},{"key":"bibr4-14732300020300S104","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199803001-00004"},{"key":"bibr5-14732300020300S104","doi-asserted-by":"publisher","DOI":"10.1177\/106002807701101104"},{"key":"bibr6-14732300020300S104","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/45.suppl_1.23"},{"key":"bibr7-14732300020300S104","first-page":"53A","volume":"20","author":"Alvart R","year":"1992","journal-title":"J Int Med Res"},{"key":"bibr8-14732300020300S104","doi-asserted-by":"publisher","DOI":"10.1016\/S0011-393X(05)80192-4"},{"key":"bibr9-14732300020300S104","first-page":"24A","volume":"20","author":"Arguello A","year":"1992","journal-title":"J Int Med Res"},{"key":"bibr10-14732300020300S104","first-page":"31A","volume":"20","author":"Biolcati AH","year":"1992","journal-title":"J Int Med Res"},{"key":"bibr11-14732300020300S104","first-page":"78D","volume":"118","author":"Rodriguez WJ","year":"1990","journal-title":"J Int Med Res"},{"key":"bibr12-14732300020300S104","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199301000-00007"},{"key":"bibr13-14732300020300S104","doi-asserted-by":"publisher","DOI":"10.1177\/00034894830920S645"},{"key":"bibr14-14732300020300S104","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199803001-00005"},{"key":"bibr15-14732300020300S104","first-page":"29","volume-title":"Countering Resistance due to Beta-lactamases. 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